Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model

Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis in normal steady states. Using mice undergoing chronic inflammatory arthritis, we investigated the relationship between hematopoiesis and bone homeostasis in pathologic conditions. We...

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Bibliographic Details
Published in:Blood 2009-11, Vol.114 (20), p.4402-4410
Main Authors: Ma, Yunglin D., Park, Changwon, Zhao, Haibo, Oduro, Kwadwo A., Tu, Xiaolin, Long, Fanxin, Allen, Paul M., Teitelbaum, Steven L., Choi, Kyunghee
Format: Article
Language:English
Subjects:
Animals
Arthritis, Experimental - complications
Arthritis, Experimental - metabolism
Arthritis, Experimental - pathology
Biological and medical sciences
Cell Differentiation - physiology
Chronic Disease
Disease Models, Animal
Diseases of the osteoarticular system
Flow Cytometry
Hematologic and hematopoietic diseases
Hematopoiesis and Stem Cells
Hematopoietic Stem Cells - cytology
Immunohistochemistry
Inflammation - metabolism
Inflammation - pathology
Inflammatory joint diseases
Medical sciences
Mice
Osteoblasts - cytology
Osteoblasts - metabolism
Osteoporosis - etiology
Reverse Transcriptase Polymerase Chain Reaction
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Summary:Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis in normal steady states. Using mice undergoing chronic inflammatory arthritis, we investigated the relationship between hematopoiesis and bone homeostasis in pathologic conditions. We demonstrate that mice undergoing chronic inflammatory arthritis displayed osteoporosis resulting from a severe defect in osteoblast function. Despite the defective osteoblast function, however, the hematopoietic stem cells from these mice exhibited normal properties in either long-term repopulation or cell cycling. Therefore, the bone-forming capacity of osteoblasts is distinct from their ability to maintain hematopoietic stem cells in chronic inflammatory conditions.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2008-12-196311