A sporadic outbreak of human brucellosis in Korea

Eleven cases of human brucellosis occurred among livestock workers and a veterinarian who lived and worked in a rural area around Jeongeup City, Jeollabuk-Do, Korea from February 2003 to August 2003. Eight of the patients had taken care of Korean native cattle that were infected with bovine brucello...

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Bibliographic Details
Published in:Journal of Korean medical science 2005-12, Vol.20 (6), p.941-946
Main Authors: Park, Mi-Yeoun, Lee, Chang-Seop, Choi, Young-Sil, Park, Seoung-Ju, Lee, Joo-Sun, Lee, Heung-Bum
Format: Article
Language:English
Subjects:
Adult
Animal Husbandry
Animals
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Antibodies, Bacterial - blood
Base Sequence
Brucella abortus - genetics
Brucella abortus - immunology
Brucella abortus - isolation & purification
Brucellosis - drug therapy
Brucellosis - epidemiology
Brucellosis - microbiology
Brucellosis - transmission
Brucellosis, Bovine - transmission
Cattle
Disease Outbreaks
DNA, Bacterial - genetics
Doxycycline - adverse effects
Doxycycline - therapeutic use
Female
Humans
Korea - epidemiology
Male
Middle Aged
Occupational Diseases - drug therapy
Occupational Diseases - epidemiology
Occupational Diseases - immunology
Occupational Diseases - microbiology
Original
Rifampin - adverse effects
Rifampin - therapeutic use
Veterinarians
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Summary:Eleven cases of human brucellosis occurred among livestock workers and a veterinarian who lived and worked in a rural area around Jeongeup City, Jeollabuk-Do, Korea from February 2003 to August 2003. Eight of the patients had taken care of Korean native cattle that were infected with bovine brucellosis and had already been slaughtered. Two of the patients had taken care of dairy cattle, and one case was a veterinarian who acquired the disease through an accidental contact with infected cattle while assisting in calf delivery. Eleven cases were identified by serologic work ups and four cases were identified via positive blood cultures. This study shows that the Republic of Korea is no longer free of human brucellosis, Brucella abortus biotype 1. We reviewed the patients' characteristics and serologic data during the one-year follow up period, and we also discuss on the efficacy and side effects of the rifampin and doxycyline regimen used for the treatment of human brucellosis.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2005.20.6.941