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Clinical Trial Design in Neonatal Pharmacology: Effect of Center Differences, With Lessons From the Pediatric Oncology Cooperative Research Experience
Survival for premature neonates has improved dramatically over the past 20 years; however, there has been minimal improvement in prematurity‐associated morbidities. Morbidity rates and assessment of outcomes vary across neonatology intensive care units (NICUs). Here, we address the reasons underlyin...
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| Published in: | Clinical pharmacology and therapeutics 2009-12, Vol.86 (6), p.589-591 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4625-8777084ed472f7f65384342c51096fa33cc208c3d806318f0c8418e6a24d8ec33 |
| container_end_page | 591 |
| container_issue | 6 |
| container_start_page | 589 |
| container_title | Clinical pharmacology and therapeutics |
| container_volume | 86 |
| creator | Moran, C Smith, P B Cohen‐Wolkowiez, M Benjamin, D K |
| description | Survival for premature neonates has improved dramatically over the past 20 years; however, there has been minimal improvement in prematurity‐associated morbidities. Morbidity rates and assessment of outcomes vary across neonatology intensive care units (NICUs). Here, we address the reasons underlying these differences, note the impact that this center variation has on trial design and interpretation, and highlight the success of the efforts in pediatric oncology to develop standards of care through the conduct of multicenter clinical trials.
Clinical Pharmacology & Therapeutics (2009) 86 6, 589–591. doi:10.1038/clpt.2009.175 |
| doi_str_mv | 10.1038/clpt.2009.175 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0009-9236 |
| ispartof | Clinical pharmacology and therapeutics, 2009-12, Vol.86 (6), p.589-591 |
| issn | 0009-9236 1532-6535 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2782890 |
| source | Wiley |
| subjects | Child, Preschool Clinical Trials as Topic - standards Cooperative Behavior Evidence-Based Medicine Humans Infant Infant, Newborn Infant, Newborn, Diseases - drug therapy Infant, Newborn, Diseases - mortality Infant, Premature Infant, Premature, Diseases - drug therapy Infant, Premature, Diseases - mortality Intensive Care Units, Neonatal Multicenter Studies as Topic - standards Practice Guidelines as Topic Quality of Health Care - standards Research Design - standards Treatment Outcome United States |
| title | Clinical Trial Design in Neonatal Pharmacology: Effect of Center Differences, With Lessons From the Pediatric Oncology Cooperative Research Experience |
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