Acute myelogenous leukemia switch lineage upon relapse to acute lymphoblastic leukemia: a case report

Acute leukemia, the most common form of cancer in children, accounts for approximately 30% of all childhood malignancies, with acute lymphoblastic leukemia being five times more frequent than acute myeloid leukemia. Lineage switch is the term that has been used to describe the phenomenon of acute le...

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Bibliographic Details
Published in:Cases journal 2009-10, Vol.2 (1), p.154-154, Article 154
Main Authors: Dorantes-Acosta, Elisa, Arreguin-Gonzalez, Farina, Rodriguez-Osorio, Carlos A, Sadowinski, Stanislaw, Pelayo, Rosana, Medina-Sanson, Aurora
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Case Report
Case studies
Diagnosis
Risk factors
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Summary:Acute leukemia, the most common form of cancer in children, accounts for approximately 30% of all childhood malignancies, with acute lymphoblastic leukemia being five times more frequent than acute myeloid leukemia. Lineage switch is the term that has been used to describe the phenomenon of acute leukemias that meet the standard French-American-British system criteria for a particular lineage (either lymphoid or myeloid) upon initial diagnosis, but meet the criteria for the opposite lineage at relapse. Many reports have documented conversions of acute lymphoblastic leukemia to acute myeloid leukemia. Here, we report the case of a 4-year-old child with acute myeloid leukemia, which upon relapse switched to acute lymphoblastic leukemia. The morphologic, phenotypic, and molecular features suggest the origin of a new leukemic clone.
ISSN:1757-1626
1757-1626
DOI:10.1186/1757-1626-2-154