Collectins and Cationic Antimicrobial Peptides of the Respiratory Epithelia

The respiratory epithelium is a primary site for the deposition of microorganisms that are acquired during inspiration. The innate immune system of the respiratory tract eliminates many of these potentially harmful agents preventing their colonization. Collectins and cationic antimicrobial peptides...

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Bibliographic Details
Published in:Veterinary Pathology 2006-09, Vol.43 (5), p.595-612
Main Authors: Grubor, B, Meyerholz, D.K, Ackermann, M.R
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
antibacterial properties
Antimicrobial Cationic Peptides - metabolism
antiviral properties
binding proteins
Collectins - metabolism
epithelium
gene expression regulation
immunity
inflammation
literature reviews
lungs
Respiratory Mucosa - metabolism
surfactants
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Summary:The respiratory epithelium is a primary site for the deposition of microorganisms that are acquired during inspiration. The innate immune system of the respiratory tract eliminates many of these potentially harmful agents preventing their colonization. Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by respiratory epithelia, which have integral roles in host defense and inflammation in the lung. Synthesis and secretion of these molecules are regulated by the developmental stage, hormones, as well as many growth and immunoregulatory factors. The purpose of this review is to discuss antimicrobial innate immune elements within the respiratory tract of healthy and pneumonic lung with emphasis on hydrophilic surfactant proteins and β-defensins.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.43-5-595