Staphylococcal Toxic Shock Syndrome Erythroderma Is Associated with Superantigenicity and Hypersensitivity

Staphylococcal toxic shock syndrome (TSS) has rarely been reported without rash and desquamation. This study describes a patient who met all criteria for TSS except erythroderma and desquamation. The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends o...

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Bibliographic Details
Published in:Clinical infectious diseases 2009-12, Vol.49 (12), p.1893-1896
Main Authors: John, Chandy C., Niermann, Micah, Sharon, Bazak, Peterson, Marnie L., Kranz, David M., Schlievert, Patrick M.
Format: Article
Language:English
Subjects:
Adolescent
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antibodies
Antigens
Bacterial diseases
Biological and medical sciences
BRIEF REPORT
Dermatitis, Exfoliative - diagnosis
Dermatitis, Exfoliative - etiology
Emergency and intensive care: infection, septic shock
Enterotoxins
Enterotoxins - immunology
Exanthema
Exfoliative dermatitis
Female
Fever
Human bacterial diseases
Humans
Hypotension
Immunoglobulins
Infectious diseases
Intensive care medicine
Medical sciences
Shock, Septic - diagnosis
Shock, Septic - etiology
Skin Tests
Staphylococcal Infections - diagnosis
Staphylococcal Infections - etiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus
Studies
Superantigens - immunology
T cell receptors
T lymphocytes
Toxicity
Toxins
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Description
Summary:Staphylococcal toxic shock syndrome (TSS) has rarely been reported without rash and desquamation. This study describes a patient who met all criteria for TSS except erythroderma and desquamation. The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on preexisting T cell hypersensitivity amplified by superantigenicity.
ISSN:1058-4838
1537-6591
DOI:10.1086/648441