Exercise and insulin: Convergence or divergence at AS160 and TBC1D1?

Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phospho...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2009-10, Vol.37 (4), p.188-195
Main Authors: Cartee, Gregory D, Funai, Katsuhiko
Format: Article
Language:English
Subjects:
Animals
Glucose Transporter Type 4 - metabolism
GTPase-Activating Proteins - metabolism
Insulin - metabolism
Mice
Muscle Contraction - physiology
Muscle, Skeletal - metabolism
Physical Conditioning, Animal - physiology
Proteins - metabolism
Rats
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Summary:Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport.
ISSN:0091-6331
1538-3008
DOI:10.1097/JES.0b013e3181b7b7c5