Oncofetal Protein IMP3 : A Novel Molecular Marker That Predicts Metastasis of Papillary and Chromophobe Renal Cell Carcinomas

• Published in: Cancer 2008-06, Vol.112 (12), p.2676-2682
• Main Authors: ZHONG JIANG, LOHSE, Christine M, CHU, Peigou G, WU, Chin-Lee, WODA, Bruce A, ROCK, Kenneth L, KWON, Eugene D
• Format: Article
• Language: English
• Subjects: Antigens, Neoplasm - analysis; Biological and medical sciences; Biomarkers, Tumor - analysis; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - pathology; Carcinoma, Renal Cell - diagnosis; Carcinoma, Renal Cell - pathology; Disease-Free Survival; Humans; Kidney Neoplasms - diagnosis; Kidney Neoplasms - pathology; Kidneys; Medical sciences; Neoplasm Proteins - analysis; Nephrology. Urinary tract diseases; RNA-Binding Proteins - analysis; Tumors; Tumors of the urinary system
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.23484

Whether an oncofetal protein, IMP3, can serve as a prognostic biomarker to predict metastasis for patients with localized papillary and chromophobe subtypes of renal cell carcinomas (RCCs) was investigated. The expression of IMP3 in 334 patients with primary papillary and chromophobe RCC from multiple medical centers was evaluated by immunohistochemistry. The 317 patients with localized papillary and chromophobe RCCs were further evaluated for outcome analyses. IMP3 was significantly increased in a subset of localized papillary and chromophobe RCCs that subsequently metastasized. Patients with localized IMP3-positive tumors (n=33; 10%) were over 10 times more likely to metastasize (risk ratio [RR], 11.38; 95% confidence interval [CI], 5.40-23.96; P