Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan

Toll-like receptors (TLRs) are pattern-recognition receptors that play an important role in innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR4 recognizes lipopolysaccharides of Gram-negative bacteria. Genetic polymorphisms within the TLR4 gene have been reported to be asso...

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Bibliographic Details
Published in:Molecular vision 2009-12, Vol.15, p.2673-2682
Main Authors: Asukata, Yuri, Ota, Masao, Meguro, Akira, Katsuyama, Yoshihiko, Ishihara, Mami, Namba, Kenichi, Kitaichi, Nobuyoshi, Morimoto, Shin-Ichiro, Kaburaki, Toshikatsu, Ando, Yasutaka, Takenaka, Shinobu, Inoko, Hidetoshi, Ohno, Shigeaki, Mizuki, Nobuhisa
Format: Article
Language:English
Subjects:
Case-Control Studies
Female
Gene Frequency - genetics
Genetic Predisposition to Disease
Haplotypes - genetics
Humans
Linkage Disequilibrium - genetics
Male
Polymorphism, Single Nucleotide - genetics
Sarcoidosis - complications
Sarcoidosis - genetics
Toll-Like Receptor 4 - genetics
Uveitis - complications
Uveitis - genetics
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Summary:Toll-like receptors (TLRs) are pattern-recognition receptors that play an important role in innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR4 recognizes lipopolysaccharides of Gram-negative bacteria. Genetic polymorphisms within the TLR4 gene have been reported to be associated with various inflammatory diseases; therefore, TLR4 appears to be a susceptibility gene for sarcoidosis. Although sarcoidosis has various clinical manifestations, its association with uveitis is more common in Japan than in other countries. The aim of this study was to investigate whether TLR4 polymorphisms were associated with sarcoidosis-related uveitis in a Japanese population. Two hundred twenty-three patients with sarcoidosis and 206 healthy control subjects were recruited at seven sites in Japan. Eight single-nucleotide polymorphisms (SNPs) in TLR4 were genotyped with a TaqMan assay, and allelic and phenotypic diversity were assessed in affected and control subjects. We found no association with susceptibility to sarcoid-related uveitis for any of the SNPs analyzed. Strong linkage disequilibrium was observed among all the SNPs analyzed (D'>/=0.78), which were located in one haplotype block. TLR4 polymorphisms do not play an important role in the development of uveitis in Japanese patients with sarcoidosis.
ISSN:1090-0535