Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor

Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen. At diagnosis many of them are already advanced and difficult to treat. We report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman, who received neoadjuvan...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2009-12, Vol.15 (46), p.5867-5870
Main Authors: Kaemmerer, Daniel, Prasad, Vikas, Daffner, Wolfgang, Hörsch, Dieter, Klöppel, Günter, Hommann, Merten, Baum, Richard P
Format: Article
Language:English
Subjects:
Adult
Case Report
Combined Modality Therapy
Female
Humans
Lymph Nodes - pathology
Lymphatic Metastasis - pathology
Neoadjuvant Therapy - methods
Neuroendocrine Tumors - pathology
Neuroendocrine Tumors - radiotherapy
Neuroendocrine Tumors - surgery
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - radiotherapy
Pancreatic Neoplasms - surgery
Radioisotopes - therapeutic use
Receptors, Peptide - metabolism
Treatment Outcome
手术切除
放射性核素
神经内分泌
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Summary:Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen. At diagnosis many of them are already advanced and difficult to treat. We report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman, who received neoadjuvant peptide receptor radionuclide therapy （PRRT） as first-line treatment. This resulted in a significant downstaging of the tumor and allowed its sub- sequent complete surgical removal. Follow-up for eighteen months revealed a complete remission. This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.15.5867