PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways

Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored. We hypothesized that the combined effect of inhibiting these three platelet activating pat...

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Bibliographic Details
Published in:FEBS letters 2009-11, Vol.583 (22), p.3618-3624
Main Authors: Jones, Chris I., Garner, Stephen F., Moraes, Leonardo A., Kaiser, William J., Rankin, Angela, Ouwehand, Willem H., Goodall, Alison H., Gibbins, Jonathan M.
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - pharmacology
ADP
Blood Platelets - drug effects
Blood Platelets - metabolism
Calcium - metabolism
Carrier Proteins - chemistry
Carrier Proteins - pharmacology
Collagen
Flow Cytometry
Humans
PECAM-1
Peptides - chemistry
Peptides - pharmacology
Platelet Activation - drug effects
Platelet Endothelial Cell Adhesion Molecule-1 - blood
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Platelet Membrane Glycoproteins - metabolism
Platelets
Signal Transduction
Thrombin
Thrombin - pharmacology
Thrombus
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Summary:Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored. We hypothesized that the combined effect of inhibiting these three platelet activating pathways may act to significantly inhibit thrombus formation. We demonstrate a negative relationship between PECAM-1 surface expression and platelet response to cross-linked collagen related peptide (CRP-XL) and ADP, and an inhibitory effect of PECAM-1 clustering on platelet response to CRP-XL, ADP and thrombin. This combined inhibition of multiple signaling pathways results in a marked reduction in thrombus formation.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2009.10.037