Engineered polymers for advanced drug delivery

Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition such as temperature, pH, and biomolec...

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Bibliographic Details
Published in:European journal of pharmaceutics and biopharmaceutics 2009-03, Vol.71 (3), p.420-430
Main Authors: Kim, Sungwon, Kim, Jong-Ho, Jeon, Oju, Kwon, Ick Chan, Park, Kinam
Format: Article
Language:English
Subjects:
Animals
Chemistry, Pharmaceutical
Controlled release
Delayed-Action Preparations
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems
Drug targeting
Humans
Hydrogen-Ion Concentration
Microspheres
Molecular imaging
Nanoparticles - administration & dosage
Nanotechnology
Polymers - chemistry
Smart polymer
Temperature
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Summary:Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates and drug-containing nano/micro-particles have been used for drug targeting. Engineered polymers and polymeric systems have also been used in new areas, such as molecular imaging as well as in nanotechnology. This review examines the engineered polymers that have been used as traditional drug delivery systems and as more recent applications in nanotechnology.
ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2008.09.021