Models for the histologic study of the skin interface with percutaneous biomaterials

Percutaneous devices are critical for health care. Access to tissue, vessels and internal organs afforded by these devices provides the means to treat and monitor many diseases. Unfortunately, such access is not restricted, and infection may compromise the usefulness of the device and even the life...

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Bibliographic Details
Published in:Biomedical materials (Bristol) 2008-09, Vol.3 (3), p.034006-034006
Main Authors: Fleckman, P, Olerud, J E
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - administration & dosage
Biocompatible Materials - chemistry
Dermatologic Surgical Procedures
Disease Models, Animal
Humans
Prosthesis-Related Infections - chemically induced
Prosthesis-Related Infections - pathology
Skin - drug effects
Skin - pathology
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Summary:Percutaneous devices are critical for health care. Access to tissue, vessels and internal organs afforded by these devices provides the means to treat and monitor many diseases. Unfortunately, such access is not restricted, and infection may compromise the usefulness of the device and even the life of the patient. New biomaterials offer the possibility of maintaining internal access while limiting microbial access, but understanding of the cutaneous/biomaterial interface and models to study this area are limited. This paper focuses on models useful for studying the morphology and biology of the intersection of skin and percutaneous biomaterials. An organ culture and a mouse model are described that offer promising possibilities for improved understanding of this critical interface.
ISSN:1748-605X
1748-6041
1748-605X
DOI:10.1088/1748-6041/3/3/034006