Beyond ribosome rescue: tmRNA and co-translational processes

tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the...

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Bibliographic Details
Published in:FEBS letters 2010-01, Vol.584 (2), p.413-419
Main Authors: Hayes, Christopher S., Keiler, Kenneth C.
Format: Article
Language:English
Subjects:
Bacteria - metabolism
Eubacteria
Protein Biosynthesis
Protein Folding
Ribosome pausing
Ribosomes - metabolism
RNA, Bacterial - physiology
SmpB
tmRNA
trans-Translation
Translation
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Summary:tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2009.11.023