Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure

Aims We compared the effects of exercise training on neurovascular control and functional capacity in men and women with chronic heart failure (HF). Methods and results Forty consecutive HF outpatients from the Heart Institute, University of Sao Paulo, Brazil were divided into the following four gro...

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Published in:European journal of heart failure 2010-01, Vol.12 (1), p.58-65
Main Authors: Antunes-Correa, Ligia M., Melo, Ruth C., Nobre, Thais S., Ueno, Linda M., Franco, Fabio G.M., Braga, Ana M.W., Rondon, Maria U.P.B., Brum, Patricia C., Barretto, Antonio C.P., Middlekauff, Holly R., Negrao, Carlos E.
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Pressure - physiology
Exercise - physiology
Exercise training
Female
Forearm blood flow
Gender
Heart failure
Heart Failure - physiopathology
Heart Rate - physiology
Humans
Male
Middle Aged
Muscle sympathetic nerve activity
Muscle, Skeletal - blood supply
Regional Blood Flow
Sex Factors
Stroke Volume - physiology
Sympathetic Nervous System - physiology
Sympathetic Nervous System - physiopathology
Treatment Outcome
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Summary:Aims We compared the effects of exercise training on neurovascular control and functional capacity in men and women with chronic heart failure (HF). Methods and results Forty consecutive HF outpatients from the Heart Institute, University of Sao Paulo, Brazil were divided into the following four groups matched by age: men exercise-trained (n = 12), men untrained (n = 10), women exercise-trained (n = 9), women untrained (n = 9). Maximal exercise capacity was determined from a maximal progressive exercise test on a cycle ergometer. Forearm blood flow was measured by venous occlusion plethysmography. Muscle sympathetic nerve activity (MSNA) was recorded directly using the technique of microneurography. There were no differences between groups in any baseline parameters. Exercise training produced a similar reduction in resting MSNA (P = 0.000002) and forearm vascular resistance (P = 0.0003), in men and women with HF. Peak VO2 was similarly increased in men and women with HF (P = 0.0003) and VE/VCO2 slope was significantly decreased in men and women with HF (P = 0.0007). There were no significant changes in left-ventricular ejection fraction in men and women with HF. Conclusion The benefits of exercise training on neurovascular control and functional capacity in patients with HF are independent of gender.
ISSN:1388-9842
1879-0844
DOI:10.1093/eurjhf/hfp168