Wall Teichoic Acid Function, Biosynthesis, and Inhibition

Off the wall: Wall teichoic acids (WTAs) are negatively charged glycopolymers found in dense arrays on the surface of Gram‐positive bacteria. WTAs have profound effects on the physiology of Gram‐positive organisms, and impact everything from cation homeostasis to antibiotic susceptibility to surviva...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2010-01, Vol.11 (1), p.35-45
Main Authors: Swoboda, Jonathan G, Campbell, Jennifer, Meredith, Timothy C, Walker, Suzanne
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antibiotics
biosynthesis
conditionally essential enzymes
Enzymes - metabolism
Glycerophosphates - biosynthesis
Glycerophosphates - chemistry
Gram-positive bacteria
Gram-Positive Bacteria - chemistry
Gram-Positive Bacteria - enzymology
Gram-Positive Bacteria - genetics
Multigene Family
Peptidoglycan - biosynthesis
Peptidoglycan - chemistry
Polysaccharides - biosynthesis
Polysaccharides - chemistry
Teichoic Acids - biosynthesis
Teichoic Acids - chemistry
wall teichoic acid (WTA)
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Summary:Off the wall: Wall teichoic acids (WTAs) are negatively charged glycopolymers found in dense arrays on the surface of Gram‐positive bacteria. WTAs have profound effects on the physiology of Gram‐positive organisms, and impact everything from cation homeostasis to antibiotic susceptibility to survival in a host. This review summarizes recent advances made toward understanding WTA function, biosynthesis and inhibition.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200900557