Organic–Inorganic Composites for Bone Drug Delivery

This review paper attempts to provide an overview in the fabrication and application of organic–inorganic based composites in the field of local drug delivery for bone. The concept of local drug delivery exists for a few decades. However, local drug delivery in bone and specially application of comp...

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Bibliographic Details
Published in:AAPS PharmSciTech 2009-12, Vol.10 (4), p.1158-1171
Main Authors: Soundrapandian, Chidambaram, Sa, Biswanath, Datta, Someswar
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - administration & dosage
Biochemistry
Biodegradation, Environmental
Biomechanical Phenomena
Biomedical and Life Sciences
Biomedicine
Biotechnology
Bone and Bones - metabolism
Drug Delivery Systems
Emulsions
Freeze Drying
Growth Substances - administration & dosage
Humans
Mini-Review
Pharmacology/Toxicology
Pharmacy
Phase Transition
Solubility
Technology, Pharmaceutical
Volatilization
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Summary:This review paper attempts to provide an overview in the fabrication and application of organic–inorganic based composites in the field of local drug delivery for bone. The concept of local drug delivery exists for a few decades. However, local drug delivery in bone and specially application of composites for delivery of drugs to bone is an area for potential research interest in the recent time. The advantages attained by an organic–inorganic composite when compared to its individual components include their ability to release drug, adopting to the natural environment and supporting local area until complete bone regeneration, which make them carriers of interest for local drug delivery for bone.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-009-9308-0