Enhanced Topical Delivery of Terbinafine Hydrochloride with Chitosan Hydrogels

Chitosan-based carriers have important potential applications for the administration of drugs. In the present study, topical gel formulations of terbinafine hydrochloride (T-HCl) were prepared using different types of chitosan at different molecular weight, and the antifungal inhibitory activity was...

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Bibliographic Details
Published in:AAPS PharmSciTech 2009-09, Vol.10 (3), p.1024-1031, Article 1024
Main Authors: Özcan, İpek, Abacı, Özlem, Uztan, Alev Haliki, Aksu, Buket, Boyacıoğlu, Hayal, Güneri, Tamer, Özer, Özgen
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacokinetics
Aspergillus - drug effects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Candida
Candida - drug effects
Chemistry, Pharmaceutical
Chitosan
Drug Delivery Systems
Drug Stability
Hardness
Hydrogels
In Vitro Techniques
Microbial Sensitivity Tests
Naphthalenes - administration & dosage
Naphthalenes - pharmacokinetics
Pharmacology/Toxicology
Pharmacy
Rats
Rats, Wistar
Research Article
Skin Absorption - physiology
Viscosity
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Summary:Chitosan-based carriers have important potential applications for the administration of drugs. In the present study, topical gel formulations of terbinafine hydrochloride (T-HCl) were prepared using different types of chitosan at different molecular weight, and the antifungal inhibitory activity was evaluated to suggest an effective formulation for the treatment of fungal infections. The characteristics of gel formulations were determined with viscosity measurements and texture profile analysis. Stability studies were performed at different temperatures during 3 months. The ex vivo permeation properties were studied through rat skin by using Franz diffusion cells. The antifungal inhibitory activity of formulations on Candida species and filamentous fungi was also examined with agar-cup method. The microbiological assay was found suitable for determination of in vitro antifungal activity of T-HCl. A marketed product was used to compare the results. The antifungal activity of T-HCl significantly increased when it was introduced into the chitosan gels. A higher drug release and the highest zone of inhibition were obtained from gels prepared with the lowest molecular weight chitosan (Protasan UP CL 213) compared to that of other chitosan gels and marketed product. These results indicated the advantages of the suggested formulations for topical antifungal therapy against Candida species and filamentous fungi.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-009-9299-x