Insulin resistance of muscle protein metabolism in aging

ABSTRACT A reduced response of older skeletal muscle to anabolic stimuli may contribute to the development of sarcopenia. We hypothesized that muscle proteins are resistant to the anabolic action of insulin in the elderly. We examined the effects of hyperinsulinemia on muscle protein metabolism in y...

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Bibliographic Details
Published in:The FASEB journal 2006-04, Vol.20 (6), p.768-769
Main Authors: Rasmussen, Blake B., Fujita, Satoshi, Wolfe, Robert R., Mittendorfer, Bettina, Roy, Mona, Rowe, Vincent L., Volpi, Elena
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - metabolism
Blood Flow Velocity
Female
Glucose - metabolism
Glucose Clamp Technique
Humans
hyperinsulinemia
Insulin - metabolism
Insulin Resistance
Leg
leg blood flow
Male
Muscle Proteins - metabolism
Muscle, Skeletal - metabolism
Phenylalanine
skeletal muscle
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Summary:ABSTRACT A reduced response of older skeletal muscle to anabolic stimuli may contribute to the development of sarcopenia. We hypothesized that muscle proteins are resistant to the anabolic action of insulin in the elderly. We examined the effects of hyperinsulinemia on muscle protein metabolism in young (25±2 year) and older (68±1 year) healthy subjects using stable isotope tracer techniques. Leg blood flow was higher in the young at baseline and increased during hyperinsulinemia, whereas it did not change in the elderly. Glucose concentrations and muscle uptake were not different between groups at baseline and during hyperinsulinemia. Leg phenylalanine net balance was not different at baseline and significantly increased in both groups with hyperinsulinemia (P
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.05-4607fje