mBtd is required to maintain signaling during murine limb development

buttonhead (btd) encodes an SP1-like transcription factor required for the generation and specification of Drosophila head segments. We identified a murine btd homolog, termed mouse Btd (mBtd), which can support btd-dependent head development in transgenic fly embryos. Functional studies show that m...

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Bibliographic Details
Published in:Genes & development 2003-11, Vol.17 (21), p.2630-2635
Main Authors: Treichel, Dieter, Schöck, Frieder, Jäckle, Herbert, Gruss, Peter, Mansouri, Ahmed
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Apoptosis - physiology
Body Patterning - physiology
buttonhead gene
DNA-Binding Proteins - metabolism
Drosophila
Extremities - embryology
Mice
Molecular Sequence Data
Research Communications
Signal Transduction - physiology
Transcription Factors - metabolism
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Summary:buttonhead (btd) encodes an SP1-like transcription factor required for the generation and specification of Drosophila head segments. We identified a murine btd homolog, termed mouse Btd (mBtd), which can support btd-dependent head development in transgenic fly embryos. Functional studies show that mBtd-deficient mice develop to term and die at birth. They exhibit brain malformations, posterior axial skeleton truncations, and shortened limbs. We present evidence that mBtd is required during early limb development to maintain, but not to initiate Wnt/beta-catenin-dependent FGF, Shh, and BMP-mediated signaling. The data indicate that mBtd represents a novel key player mediating proximodistal outgrowth of the limb.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.274103