Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study

Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking. To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomani...

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Bibliographic Details
Published in:British journal of psychiatry 2008-09, Vol.193 (3), p.216-221
Main Authors: Chamberlain, Samuel R., Menzies, Lara A., Fineberg, Naomi A., del Campo, Natalia, Suckling, John, Craig, Kevin, Müller, Ulrich, Robbins, Trevor W., Bullmore, Edward T., Sahakian, Barbara J.
Format: Article
Language:English
Subjects:
Adult
Animal models
Brain
Brain - abnormalities
Brain - pathology
Brain Mapping
Case-Control Studies
Cerebral Cortex - pathology
Child development
Cognition
Computational neuroscience
Emotional regulation
Female
Hair
Hippocampus
Humans
Informed consent
Magnetic Resonance Imaging
Male
Medical imaging
Morphology
Morphometry
Neostriatum
Neural networks
Neurobiology
Neuroimaging
Neurosciences
Neuroses
NMR
Nuclear magnetic resonance
Obsessive compulsive disorder
Psychiatric disorders
Psychiatry
Substantia alba
Substantia grisea
Tourette syndrome
Trichotillomania
Trichotillomania - pathology
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Summary:Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking. To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania. Eighteen patients with DSM-IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry. Patients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally. Trichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.107.048314