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Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking. To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomani...
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| Published in: | British journal of psychiatry 2008-09, Vol.193 (3), p.216-221 |
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| container_end_page | 221 |
| container_issue | 3 |
| container_start_page | 216 |
| container_title | British journal of psychiatry |
| container_volume | 193 |
| creator | Chamberlain, Samuel R. Menzies, Lara A. Fineberg, Naomi A. del Campo, Natalia Suckling, John Craig, Kevin Müller, Ulrich Robbins, Trevor W. Bullmore, Edward T. Sahakian, Barbara J. |
| description | Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking.
To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania.
Eighteen patients with DSM-IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry.
Patients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally.
Trichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research. |
| doi_str_mv | 10.1192/bjp.bp.107.048314 |
| format | article |
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To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania.
Eighteen patients with DSM-IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry.
Patients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally.
Trichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.bp.107.048314</identifier><identifier>PMID: 18757980</identifier><identifier>CODEN: BJPYAJ</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Animal models ; Brain ; Brain - abnormalities ; Brain - pathology ; Brain Mapping ; Case-Control Studies ; Cerebral Cortex - pathology ; Child development ; Cognition ; Computational neuroscience ; Emotional regulation ; Female ; Hair ; Hippocampus ; Humans ; Informed consent ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Morphology ; Morphometry ; Neostriatum ; Neural networks ; Neurobiology ; Neuroimaging ; Neurosciences ; Neuroses ; NMR ; Nuclear magnetic resonance ; Obsessive compulsive disorder ; Psychiatric disorders ; Psychiatry ; Substantia alba ; Substantia grisea ; Tourette syndrome ; Trichotillomania ; Trichotillomania - pathology</subject><ispartof>British journal of psychiatry, 2008-09, Vol.193 (3), p.216-221</ispartof><rights>Copyright © Royal College of Psychiatrists, 2008</rights><rights>2008 This article is published under (http://creativecommons.org/licenses/by-nc/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Royal College of Psychiatrists 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-43cbd2582c6f758221805c348ef5f3bc8653172cf4d115538561bfecc5a48bf73</citedby><cites>FETCH-LOGICAL-c526t-43cbd2582c6f758221805c348ef5f3bc8653172cf4d115538561bfecc5a48bf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2315598903/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2315598903?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,12845,21393,21394,27923,27924,30998,30999,33610,33611,34529,34530,43732,44114,72831,74092,74510</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18757980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chamberlain, Samuel R.</creatorcontrib><creatorcontrib>Menzies, Lara A.</creatorcontrib><creatorcontrib>Fineberg, Naomi A.</creatorcontrib><creatorcontrib>del Campo, Natalia</creatorcontrib><creatorcontrib>Suckling, John</creatorcontrib><creatorcontrib>Craig, Kevin</creatorcontrib><creatorcontrib>Müller, Ulrich</creatorcontrib><creatorcontrib>Robbins, Trevor W.</creatorcontrib><creatorcontrib>Bullmore, Edward T.</creatorcontrib><creatorcontrib>Sahakian, Barbara J.</creatorcontrib><title>Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking.
To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania.
Eighteen patients with DSM-IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry.
Patients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally.
Trichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research.</description><subject>Adult</subject><subject>Animal models</subject><subject>Brain</subject><subject>Brain - abnormalities</subject><subject>Brain - pathology</subject><subject>Brain Mapping</subject><subject>Case-Control Studies</subject><subject>Cerebral Cortex - pathology</subject><subject>Child development</subject><subject>Cognition</subject><subject>Computational neuroscience</subject><subject>Emotional regulation</subject><subject>Female</subject><subject>Hair</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Informed consent</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Morphology</subject><subject>Morphometry</subject><subject>Neostriatum</subject><subject>Neural networks</subject><subject>Neurobiology</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Neuroses</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Obsessive compulsive disorder</subject><subject>Psychiatric disorders</subject><subject>Psychiatry</subject><subject>Substantia alba</subject><subject>Substantia grisea</subject><subject>Tourette syndrome</subject><subject>Trichotillomania</subject><subject>Trichotillomania - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chamberlain, Samuel R.</au><au>Menzies, Lara A.</au><au>Fineberg, Naomi A.</au><au>del Campo, Natalia</au><au>Suckling, John</au><au>Craig, Kevin</au><au>Müller, Ulrich</au><au>Robbins, Trevor W.</au><au>Bullmore, Edward T.</au><au>Sahakian, Barbara J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>2008-09</date><risdate>2008</risdate><volume>193</volume><issue>3</issue><spage>216</spage><epage>221</epage><pages>216-221</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><coden>BJPYAJ</coden><abstract>Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking.
To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania.
Eighteen patients with DSM-IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry.
Patients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally.
Trichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>18757980</pmid><doi>10.1192/bjp.bp.107.048314</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of psychiatry, 2008-09, Vol.193 (3), p.216-221 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Social Science Premium Collection; Sociology Collection; Cambridge University Press |
| subjects | Adult Animal models Brain Brain - abnormalities Brain - pathology Brain Mapping Case-Control Studies Cerebral Cortex - pathology Child development Cognition Computational neuroscience Emotional regulation Female Hair Hippocampus Humans Informed consent Magnetic Resonance Imaging Male Medical imaging Morphology Morphometry Neostriatum Neural networks Neurobiology Neuroimaging Neurosciences Neuroses NMR Nuclear magnetic resonance Obsessive compulsive disorder Psychiatric disorders Psychiatry Substantia alba Substantia grisea Tourette syndrome Trichotillomania Trichotillomania - pathology |
| title | Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study |
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