An efficient boric acid-mediated preparation of α-hydroxyamides

An efficient methodology for the preparation of α-hydroxyamides via boric acid-mediated addition of isonitriles on to aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles. An...

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Bibliographic Details
Published in:Tetrahedron letters 2010-02, Vol.51 (5), p.779-782
Main Authors: Sravan Kumar, J., Jonnalagadda, Subash C., Mereddy, Venkatram R.
Format: Article
Language:English
Subjects:
Benzoxaboroles
Boric acid
Isonitriles
Multicomponent reactions
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Summary:An efficient methodology for the preparation of α-hydroxyamides via boric acid-mediated addition of isonitriles on to aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles. An efficient methodology for the preparation of α-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.12.008