Phage type conversion in Salmonella enterica serotype Enteritidis caused by the introduction of a resistance plasmid of incompatibility group X (IncX)

The plasmid pOG670, a 54 kb, conjugative plasmid that specifies resistance to ampicillin and kanamycin and belonging to the incompatibility group X (IncX), was transferred into 10 isolates of Salmonella enterica serotype Enteritidis belonging to 10 different phage types (PT1, 2, 3, 4, 8, 9, 9b, 10,...

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Bibliographic Details
Published in:Epidemiology and infection 1999-02, Vol.122 (1), p.19-22
Main Authors: BROWN, D. J., BAGGESEN, D. L., PLATT, D. J., OLSEN, J. E.
Format: Article
Language:English
Subjects:
Agriculture
Animals
Bacteriology
Bacteriophage Typing
Bacteriophages
Biological and medical sciences
Conjugation, Genetic - genetics
DNA, Bacterial - genetics
Drug Resistance, Microbial - genetics
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genetics
Microbial Sensitivity Tests
Microbiology
Phylogeny
Plasmids
Poultry - microbiology
R Factors - genetics
Salmonella
Salmonella enterica
Salmonella enteritidis
Salmonella enteritidis - classification
Salmonella enteritidis - genetics
Salmonella typhimurium
Veterinary medical education
Virulence
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Description
Summary:The plasmid pOG670, a 54 kb, conjugative plasmid that specifies resistance to ampicillin and kanamycin and belonging to the incompatibility group X (IncX), was transferred into 10 isolates of Salmonella enterica serotype Enteritidis belonging to 10 different phage types (PT1, 2, 3, 4, 8, 9, 9b, 10, 11 and 13). Acquisition of the plasmid by these strains did not result in the loss of any resident plasmids but resulted in phage type conversion in 8 of the 10 strains (PT1, 2, 4, 8, 9, 9b, 10 and 11). The observed changes in phage type were found to result from the loss of sensitivity to 3 of the 10 typing phages used (phages 3, 5 and 7). Where the conversion resulted in a change to a defined phage type, both the new and original PTs belonged to the same, previously described, evolutionary lines. Enteritidis PTs 1, 4 and 8, commonly associated with poultry world-wide, were converted to PTs 21, 6 and 13a respectively. The results indicate a different route for phage type conversion Enteritidis from others reported in the literature and, although IncX plasmids are not normally present in PT8 or PT13a, may suggest a possible mechanism/link connecting these phage types.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268898001794