Proteinuria is associated with persistence of antibody to streptococcal M protein in Aboriginal Australians

• Published in: Epidemiology and infection 1999-02, Vol.122 (1), p.67-75
• Main Authors: GOODFELLOW, A. M., HOY, W. E., SRIPRAKASH, K. S., DALY, M. J., REEVE, M. P., MATHEWS, J. D.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age distribution; Albuminuria; Albuminuria - immunology; Albuminuria - microbiology; Antibodies; Antibodies, Bacterial - blood; Antigens, Bacterial; Bacterial diseases; Bacterial Outer Membrane Proteins; Bacteriology; Biological and medical sciences; Carrier Proteins; Child; Childhood; Connectin; Cross-Sectional Studies; Diabetic nephropathies; Endemic Diseases - statistics & numerical data; Epidemiology; Fundamental and applied biological sciences. Psychology; Glomerulonephritis; Human bacterial diseases; Humans; Infections; Infectious diseases; Kidney Failure, Chronic - microbiology; Medical sciences; Microbiology; Middle Aged; Muscle Proteins; Myeloma Proteins; Northern Territory; Obesity - complications; Overweight; Prospective Studies; Proteinuria; Regression Analysis; Risk Factors; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcal Infections - complications; Streptococcus; Streptococcus pyogenes - immunology
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268898001812

Aboriginal communities in Northern Australia with high rates of group A streptococcal (GAS) skin infection in childhood also have high rates of renal failure in adult life. In a cross-sectional study of one such high risk community, albuminuria was used as a marker of renal disease. The prevalence of albuminuria increased from 0/52 in subjects aged 10–19 years to 10/29 (32·9%) in those aged 50 or more (P