Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis

Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sar...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical and experimental pathology 2009-11, Vol.3 (2), p.217-221
Main Authors: Rong, Rong, Doxtader, Erika E, Tull, Jamie, de la Roza, Gustavo, Zhang, Shengle
Format: Article
Language:English
Subjects:
Adult
Biopsy
Case Report
Chromosomes, Human, Pair 18
Chromosomes, Human, X
Follow-Up Studies
Humans
Immunohistochemistry - methods
In Situ Hybridization, Fluorescence
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Neoplasm Metastasis
Neoplasm Proteins - genetics
Oncogene Proteins, Fusion - genetics
Repressor Proteins - genetics
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Synovial - diagnosis
Sarcoma, Synovial - genetics
Sarcoma, Synovial - secondary
Sequence Analysis, DNA
Translocation, Genetic
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis. The tumor was negative for EMA and cytokeratin, previously reported as the most sensitive immunostaining markers for synovial sarcomas. SYT-SSX gene fusion, characteristic for synovial sarcoma, was identified in this case by FISH and RT-PCR assays.
ISSN:1936-2625