Loading…

Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis

Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sar...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of clinical and experimental pathology 2009-11, Vol.3 (2), p.217-221
Main Authors:	Rong, Rong, Doxtader, Erika E, Tull, Jamie, de la Roza, Gustavo, Zhang, Shengle
Format:	Article
Language:	English
Subjects:	Adult Biopsy Case Report Chromosomes, Human, Pair 18 Chromosomes, Human, X Follow-Up Studies Humans Immunohistochemistry - methods In Situ Hybridization, Fluorescence Lung Neoplasms - genetics Lung Neoplasms - pathology Male Neoplasm Metastasis Neoplasm Proteins - genetics Oncogene Proteins, Fusion - genetics Repressor Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Sarcoma, Synovial - diagnosis Sarcoma, Synovial - genetics Sarcoma, Synovial - secondary Sequence Analysis, DNA Translocation, Genetic
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by
cites
container_end_page	221
container_issue	2
container_start_page	217
container_title	International journal of clinical and experimental pathology
container_volume	3
creator	Rong, Rong Doxtader, Erika E Tull, Jamie de la Roza, Gustavo Zhang, Shengle
description	Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis. The tumor was negative for EMA and cytokeratin, previously reported as the most sensitive immunostaining markers for synovial sarcomas. SYT-SSX gene fusion, characteristic for synovial sarcoma, was identified in this case by FISH and RT-PCR assays.
format	article
fullrecord	<record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2810002</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20126590</sourcerecordid><originalsourceid>FETCH-LOGICAL-p265t-7b21ac3344873948ab4d00143e81cc7a0684f26987c8400b00913456907a43663</originalsourceid><addsrcrecordid>eNpVkM1OwzAQhCMkREvhFZBfINL6J07CAQlV_ElFXOAcbRynNTh2FDut8vYEURCc9rA738zsSbKkJZcpkyxbJOchvANIygScJQsGlMmshGVyeNYRQ8RoFOm9H-xEGtO2etAuGoy6IZ13vt9hmA_C5PzeoCUBB-U7JNETO7otOZi4I6P7cP7gSD-YDofpmuCstVqNFgey1U5_eaBDOwUTLpLTFm3Ql8e5St7u717Xj-nm5eFpfbtJ-zlgTPOaUVScC1HkvBQF1qIBoILrgiqVI8hCtEyWRa4KAVADlJSLTJaQo-BS8lVy883tx7rTjZprDWirY8bKo6n-b5zZVVu_r1hBAYDNgKu_gF_lzwv5J9a2b2o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis</title><source>PubMed Central</source><creator>Rong, Rong ; Doxtader, Erika E ; Tull, Jamie ; de la Roza, Gustavo ; Zhang, Shengle</creator><creatorcontrib>Rong, Rong ; Doxtader, Erika E ; Tull, Jamie ; de la Roza, Gustavo ; Zhang, Shengle</creatorcontrib><description>Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis. The tumor was negative for EMA and cytokeratin, previously reported as the most sensitive immunostaining markers for synovial sarcomas. SYT-SSX gene fusion, characteristic for synovial sarcoma, was identified in this case by FISH and RT-PCR assays.</description><identifier>EISSN: 1936-2625</identifier><identifier>PMID: 20126590</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Adult ; Biopsy ; Case Report ; Chromosomes, Human, Pair 18 ; Chromosomes, Human, X ; Follow-Up Studies ; Humans ; Immunohistochemistry - methods ; In Situ Hybridization, Fluorescence ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Male ; Neoplasm Metastasis ; Neoplasm Proteins - genetics ; Oncogene Proteins, Fusion - genetics ; Repressor Proteins - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sarcoma, Synovial - diagnosis ; Sarcoma, Synovial - genetics ; Sarcoma, Synovial - secondary ; Sequence Analysis, DNA ; Translocation, Genetic</subject><ispartof>International journal of clinical and experimental pathology, 2009-11, Vol.3 (2), p.217-221</ispartof><rights>IJCEP Copyright © 2010</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810002/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810002/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20126590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rong, Rong</creatorcontrib><creatorcontrib>Doxtader, Erika E</creatorcontrib><creatorcontrib>Tull, Jamie</creatorcontrib><creatorcontrib>de la Roza, Gustavo</creatorcontrib><creatorcontrib>Zhang, Shengle</creatorcontrib><title>Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis</title><title>International journal of clinical and experimental pathology</title><addtitle>Int J Clin Exp Pathol</addtitle><description>Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis. The tumor was negative for EMA and cytokeratin, previously reported as the most sensitive immunostaining markers for synovial sarcomas. SYT-SSX gene fusion, characteristic for synovial sarcoma, was identified in this case by FISH and RT-PCR assays.</description><subject>Adult</subject><subject>Biopsy</subject><subject>Case Report</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Chromosomes, Human, X</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Repressor Proteins - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sarcoma, Synovial - diagnosis</subject><subject>Sarcoma, Synovial - genetics</subject><subject>Sarcoma, Synovial - secondary</subject><subject>Sequence Analysis, DNA</subject><subject>Translocation, Genetic</subject><issn>1936-2625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpVkM1OwzAQhCMkREvhFZBfINL6J07CAQlV_ElFXOAcbRynNTh2FDut8vYEURCc9rA738zsSbKkJZcpkyxbJOchvANIygScJQsGlMmshGVyeNYRQ8RoFOm9H-xEGtO2etAuGoy6IZ13vt9hmA_C5PzeoCUBB-U7JNETO7otOZi4I6P7cP7gSD-YDofpmuCstVqNFgey1U5_eaBDOwUTLpLTFm3Ql8e5St7u717Xj-nm5eFpfbtJ-zlgTPOaUVScC1HkvBQF1qIBoILrgiqVI8hCtEyWRa4KAVADlJSLTJaQo-BS8lVy883tx7rTjZprDWirY8bKo6n-b5zZVVu_r1hBAYDNgKu_gF_lzwv5J9a2b2o</recordid><startdate>20091125</startdate><enddate>20091125</enddate><creator>Rong, Rong</creator><creator>Doxtader, Erika E</creator><creator>Tull, Jamie</creator><creator>de la Roza, Gustavo</creator><creator>Zhang, Shengle</creator><general>e-Century Publishing Corporation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20091125</creationdate><title>Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis</title><author>Rong, Rong ; Doxtader, Erika E ; Tull, Jamie ; de la Roza, Gustavo ; Zhang, Shengle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p265t-7b21ac3344873948ab4d00143e81cc7a0684f26987c8400b00913456907a43663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biopsy</topic><topic>Case Report</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Chromosomes, Human, X</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Repressor Proteins - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sarcoma, Synovial - diagnosis</topic><topic>Sarcoma, Synovial - genetics</topic><topic>Sarcoma, Synovial - secondary</topic><topic>Sequence Analysis, DNA</topic><topic>Translocation, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>Rong, Rong</creatorcontrib><creatorcontrib>Doxtader, Erika E</creatorcontrib><creatorcontrib>Tull, Jamie</creatorcontrib><creatorcontrib>de la Roza, Gustavo</creatorcontrib><creatorcontrib>Zhang, Shengle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of clinical and experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rong, Rong</au><au>Doxtader, Erika E</au><au>Tull, Jamie</au><au>de la Roza, Gustavo</au><au>Zhang, Shengle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis</atitle><jtitle>International journal of clinical and experimental pathology</jtitle><addtitle>Int J Clin Exp Pathol</addtitle><date>2009-11-25</date><risdate>2009</risdate><volume>3</volume><issue>2</issue><spage>217</spage><epage>221</epage><pages>217-221</pages><eissn>1936-2625</eissn><abstract>Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other "small blue cell tumors" based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis. The tumor was negative for EMA and cytokeratin, previously reported as the most sensitive immunostaining markers for synovial sarcomas. SYT-SSX gene fusion, characteristic for synovial sarcoma, was identified in this case by FISH and RT-PCR assays.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>20126590</pmid><tpages>5</tpages></addata></record>
fulltext	fulltext
identifier	EISSN: 1936-2625
ispartof	International journal of clinical and experimental pathology, 2009-11, Vol.3 (2), p.217-221
issn	1936-2625
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2810002
source	PubMed Central
subjects	Adult Biopsy Case Report Chromosomes, Human, Pair 18 Chromosomes, Human, X Follow-Up Studies Humans Immunohistochemistry - methods In Situ Hybridization, Fluorescence Lung Neoplasms - genetics Lung Neoplasms - pathology Male Neoplasm Metastasis Neoplasm Proteins - genetics Oncogene Proteins, Fusion - genetics Repressor Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Sarcoma, Synovial - diagnosis Sarcoma, Synovial - genetics Sarcoma, Synovial - secondary Sequence Analysis, DNA Translocation, Genetic
title	Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T14%3A25%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metastatic%20poorly%20differentiated%20monophasic%20synovial%20sarcoma%20to%20lung%20with%20unknown%20primary:%20a%20molecular%20genetic%20analysis&rft.jtitle=International%20journal%20of%20clinical%20and%20experimental%20pathology&rft.au=Rong,%20Rong&rft.date=2009-11-25&rft.volume=3&rft.issue=2&rft.spage=217&rft.epage=221&rft.pages=217-221&rft.eissn=1936-2625&rft_id=info:doi/&rft_dat=%3Cpubmed%3E20126590%3C/pubmed%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p265t-7b21ac3344873948ab4d00143e81cc7a0684f26987c8400b00913456907a43663%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/20126590&rfr_iscdi=true