Toward the dynamic interactome: it's about time

Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different time...

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Bibliographic Details
Published in:Briefings in bioinformatics 2010-01, Vol.11 (1), p.15-29
Main Authors: Przytycka, Teresa M., Singh, Mona, Slonim, Donna K.
Format: Article
Language:English
Subjects:
Bioinformatics
Biology
Biomedical research
Proteins - chemistry
Systems Biology
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Summary:Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.
ISSN:1467-5463
1477-4054
DOI:10.1093/bib/bbp057