The effect of pretreatment with thiopental on reducing pain induced by rocuronium injection

We examined whether pretreatment with a small dose of thiopental was effective in reducing pain induced by the intravenous injection of rocuronium. Withdrawal movement was used to assess pain reduction. Ninety patients were randomly assigned to one of two groups: patients in the control group were p...

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Bibliographic Details
Published in:Yonsei medical journal 2005-12, Vol.46 (6), p.765-768
Main Authors: Park, Jong-Taek, Choi, Jae-Chan, Yoo, Young-Soo, Lee, Young-Bok, Kim, Soon-Yul, Lim, Hyun-Kyo
Format: Article
Language:English
Subjects:
Adult
Androstanols - adverse effects
Anesthetics, Intravenous
Female
Humans
Injections, Intravenous
Male
Middle Aged
Neuromuscular Nondepolarizing Agents - adverse effects
Original
Pain - chemically induced
Pain - prevention & control
Pain Measurement
Thiopental - therapeutic use
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Summary:We examined whether pretreatment with a small dose of thiopental was effective in reducing pain induced by the intravenous injection of rocuronium. Withdrawal movement was used to assess pain reduction. Ninety patients were randomly assigned to one of two groups: patients in the control group were pretreated with 2 mL saline, and those in the thiopental group were pretreated with 2 mL (50 mg) thiopental. Thiopental 5 mg/kg was injected intravenously. After a loss of consciousness, the upper arm was compressed with a rubber tourniquet, and the pretreatment drugs were administered. Thirty seconds later the tourniquet was removed and 0.6 mg/kg rocuronium was administered. Withdrawal movement was assessed using a four-grade scale: no movement, movement limited to the wrist, to the elbow or to the shoulder. The frequency of withdrawal movement in the group pretreated with thiopental was lower than in the control group (34 vs. 13, p < 0.05). We concluded that pretreatment with 2 mL (50 mg) thiopental is effective in reducing pain caused by the intravenous injection of rocuronium.
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2005.46.6.765