Phylogeographic patterns exhibited by Ontario rabies virus variants

A previous study on N gene variation of rabies viruses circulating in Ontario red foxes identified four viral variants. This study confirms the geographical localization of these variants and extends the analysis to the less conserved G gene of these viruses. A greater number of regionally localized...

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Bibliographic Details
Published in:Epidemiology and infection 1999-10, Vol.123 (2), p.325-336
Main Authors: NADIN-DAVIS, S. A., SAMPATH, M. I., CASEY, G. A., TINLINE, R. R., WANDELER, A. I.
Format: Article
Language:English
Subjects:
AG gene
Amino Acid Sequence
AN gene
Animal viral diseases
Animals
Biological and medical sciences
Canada, Ontario
DNA, Viral - chemistry
Epidemiology
Foxes
Foxes - virology
Fundamental and applied biological sciences. Psychology
Genetic variation
Glycoproteins
Incidence
Infectious diseases
Medical sciences
Mephitidae - virology
Microbiology
Molecular Epidemiology
Molecular Sequence Data
Nucleotide sequences
Ontario - epidemiology
Phylogenetics
Phylogeny
Polymerase chain reaction
Polymorphism, Restriction Fragment Length
Rabies
Rabies - epidemiology
Rabies virus
Rabies virus - genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequencing
Viral diseases
Virology
Viruses
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Summary:A previous study on N gene variation of rabies viruses circulating in Ontario red foxes identified four viral variants. This study confirms the geographical localization of these variants and extends the analysis to the less conserved G gene of these viruses. A greater number of regionally localized variants was revealed and their phylogenetic relationships have been examined. Ongoing surveillance on recent disease outbreaks revealed that variants do not always persist in specific areas. The distribution of these variants did however appear to be influenced by topographical features of the study area likely to affect host animal movements and contacts. The majority of G gene base changes were synonymous and limited glycoprotein sequence variation predominantly to the C-terminal transmembrane and endo-domains. These data are most readily explained by random appearance of genetic viral variants followed by their spread throughout sub-populations of the fox host according to the easiest routes of transmission.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268899002885