The Incidence, Characteristics, and Presentation of Dengue Virus Infections during Infancy

Infants are a vulnerable and unique population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. D...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2010-02, Vol.82 (2), p.330-336
Main Authors: Capeding, Rosario Z, Brion, Job D, Caponpon, Mercydina M, Gibbons, Robert V, Jarman, Richard G, Yoon, In-Kyu, Libraty, Daniel H
Format: Article
Language:English
Subjects:
Age Distribution
Antibodies, Viral - blood
Antibodies, Viral - immunology
Arboviroses
Biological and medical sciences
Dengue - diagnosis
Dengue - epidemiology
Dengue fevers
Dengue Virus - immunology
Enzyme-Linked Immunosorbent Assay
Female
Human viral diseases
Humans
Immunoglobulin M - blood
Immunoglobulin M - immunology
Incidence
Infant
Infectious diseases
Male
Medical sciences
Philippines - epidemiology
Tropical viral diseases
Viral diseases
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Summary:Infants are a vulnerable and unique population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity, ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3-8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses. Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2010.09-0542