Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome. Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. Th...

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Bibliographic Details
Published in:British journal of cancer 2010-01, Vol.102 (1), p.23-26
Main Authors: Donaldson, S B, Buckley, D L, O'Connor, J P, Davidson, S E, Carrington, B M, Jones, A P, West, C M L
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood supply
Adenocarcinoma - radiotherapy
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Adenosquamous - blood supply
Carcinoma, Adenosquamous - radiotherapy
Carcinoma, Squamous Cell - blood supply
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - radiotherapy
Contrast Media
Disease-Free Survival
Drug Resistance
Epidemiology
Female
Female genital diseases
Follow-Up Studies
Gadolinium DTPA
Gynecology. Andrology. Obstetrics
Humans
Image Processing, Computer-Assisted - methods
Image Processing, Computer-Assisted - statistics & numerical data
Kaplan-Meier Estimate
Magnetic Resonance Imaging - methods
Medical sciences
Middle Aged
Molecular Medicine
Neoplasm Metastasis
Neoplasm Recurrence, Local - epidemiology
Neoplasm, Residual
Neovascularization, Pathologic - pathology
Oncology
Retrospective Studies
Short Communication
Tumors
Uterine Cervical Neoplasms - blood supply
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - radiotherapy
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Summary:Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome. Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels ( E F ) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS). Results: Tumours with high E F had a significantly poorer probability of DFS than those with low E F ( P =0.011). Interpretation: E F is a simple imaging biomarker that should be studied further in a multi-centre setting.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6605415