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Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome. Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. Th...
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| Published in: | British journal of cancer 2010-01, Vol.102 (1), p.23-26 |
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| container_end_page | 26 |
| container_issue | 1 |
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| container_title | British journal of cancer |
| container_volume | 102 |
| creator | Donaldson, S B Buckley, D L O'Connor, J P Davidson, S E Carrington, B M Jones, A P West, C M L |
| description | Background:
There is a need for simple imaging parameters capable of predicting therapeutic outcome.
Methods:
This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (
E
F
) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).
Results:
Tumours with high
E
F
had a significantly poorer probability of DFS than those with low
E
F
(
P
=0.011).
Interpretation:
E
F
is a simple imaging biomarker that should be studied further in a multi-centre setting. |
| doi_str_mv | 10.1038/sj.bjc.6605415 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2813759</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1933720141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-e3eb8bf4842ac523eaa8c4164f4568c20e6fcc247d6aa065e3850bd023eaa8ff3</originalsourceid><addsrcrecordid>eNp1kl-L1DAUxYso7rj66psSBPGps0n6J-mLIMuqCyuC6HO4TW9nMrTpmLSj-wn82t6xdVYFn0Jyf-eeezlJkqeCrwXP9EXcreudXZclL3JR3EtWoshkKrRU95MV51ylvJL8LHkU446uFdfqYXImKnrUmVglP678Frx1fsPaAHZ0g2c9QpwCNmyKx_fm1kPvLLODHwPEMcVfEqp_-HTN9gQ6O0bWuEg6TNuAyEh_cAfomPNsD6NDT8Q3N26ZhUBuQw9saNm4RWaR0O-PkwctdBGfLOd58uXt1efL9-nNx3fXl29uUltwTdYZ1rpuc51LsIXMEEDbXJR5mxeltpJj2Vorc9WUALwsMNMFrxs-k22bnSev5777qe6xsXjcqTP74HoIt2YAZ_6ueLc1m-FgpBaZKipq8GppEIavE8bR9C5a7DrwOEzRqCyXUnKVE_niH3I3TMHTdkbKqlKV4oqg9QzZMMQYsD2NIrg5JmzizlDCZkmYBM__XOAOXyIl4OUCQLTQUaoUbzxxZK0yLY7cxcxFKvkNhrvx_mv9bFZ4GOl_nFr-rv8EIdTM8A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229979707</pqid></control><display><type>article</type><title>Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix</title><source>PubMed Central</source><creator>Donaldson, S B ; Buckley, D L ; O'Connor, J P ; Davidson, S E ; Carrington, B M ; Jones, A P ; West, C M L</creator><creatorcontrib>Donaldson, S B ; Buckley, D L ; O'Connor, J P ; Davidson, S E ; Carrington, B M ; Jones, A P ; West, C M L</creatorcontrib><description>Background:
There is a need for simple imaging parameters capable of predicting therapeutic outcome.
Methods:
This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (
E
F
) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).
Results:
Tumours with high
E
F
had a significantly poorer probability of DFS than those with low
E
F
(
P
=0.011).
Interpretation:
E
F
is a simple imaging biomarker that should be studied further in a multi-centre setting.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6605415</identifier><identifier>PMID: 19920831</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenocarcinoma - blood supply ; Adenocarcinoma - radiotherapy ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Adenosquamous - blood supply ; Carcinoma, Adenosquamous - radiotherapy ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; Contrast Media ; Disease-Free Survival ; Drug Resistance ; Epidemiology ; Female ; Female genital diseases ; Follow-Up Studies ; Gadolinium DTPA ; Gynecology. Andrology. Obstetrics ; Humans ; Image Processing, Computer-Assisted - methods ; Image Processing, Computer-Assisted - statistics & numerical data ; Kaplan-Meier Estimate ; Magnetic Resonance Imaging - methods ; Medical sciences ; Middle Aged ; Molecular Medicine ; Neoplasm Metastasis ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm, Residual ; Neovascularization, Pathologic - pathology ; Oncology ; Retrospective Studies ; Short Communication ; Tumors ; Uterine Cervical Neoplasms - blood supply ; Uterine Cervical Neoplasms - mortality ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>British journal of cancer, 2010-01, Vol.102 (1), p.23-26</ispartof><rights>The Author(s) 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 5, 2010</rights><rights>Copyright © 2010 Cancer Research UK 2010 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-e3eb8bf4842ac523eaa8c4164f4568c20e6fcc247d6aa065e3850bd023eaa8ff3</citedby><cites>FETCH-LOGICAL-c508t-e3eb8bf4842ac523eaa8c4164f4568c20e6fcc247d6aa065e3850bd023eaa8ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813759/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813759/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22973811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19920831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donaldson, S B</creatorcontrib><creatorcontrib>Buckley, D L</creatorcontrib><creatorcontrib>O'Connor, J P</creatorcontrib><creatorcontrib>Davidson, S E</creatorcontrib><creatorcontrib>Carrington, B M</creatorcontrib><creatorcontrib>Jones, A P</creatorcontrib><creatorcontrib>West, C M L</creatorcontrib><title>Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
There is a need for simple imaging parameters capable of predicting therapeutic outcome.
Methods:
This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (
E
F
) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).
Results:
Tumours with high
E
F
had a significantly poorer probability of DFS than those with low
E
F
(
P
=0.011).
Interpretation:
E
F
is a simple imaging biomarker that should be studied further in a multi-centre setting.</description><subject>Adenocarcinoma - blood supply</subject><subject>Adenocarcinoma - radiotherapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Adenosquamous - blood supply</subject><subject>Carcinoma, Adenosquamous - radiotherapy</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Contrast Media</subject><subject>Disease-Free Survival</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follow-Up Studies</subject><subject>Gadolinium DTPA</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Image Processing, Computer-Assisted - statistics & numerical data</subject><subject>Kaplan-Meier Estimate</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm, Residual</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Oncology</subject><subject>Retrospective Studies</subject><subject>Short Communication</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - blood supply</subject><subject>Uterine Cervical Neoplasms - mortality</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kl-L1DAUxYso7rj66psSBPGps0n6J-mLIMuqCyuC6HO4TW9nMrTpmLSj-wn82t6xdVYFn0Jyf-eeezlJkqeCrwXP9EXcreudXZclL3JR3EtWoshkKrRU95MV51ylvJL8LHkU446uFdfqYXImKnrUmVglP678Frx1fsPaAHZ0g2c9QpwCNmyKx_fm1kPvLLODHwPEMcVfEqp_-HTN9gQ6O0bWuEg6TNuAyEh_cAfomPNsD6NDT8Q3N26ZhUBuQw9saNm4RWaR0O-PkwctdBGfLOd58uXt1efL9-nNx3fXl29uUltwTdYZ1rpuc51LsIXMEEDbXJR5mxeltpJj2Vorc9WUALwsMNMFrxs-k22bnSev5777qe6xsXjcqTP74HoIt2YAZ_6ueLc1m-FgpBaZKipq8GppEIavE8bR9C5a7DrwOEzRqCyXUnKVE_niH3I3TMHTdkbKqlKV4oqg9QzZMMQYsD2NIrg5JmzizlDCZkmYBM__XOAOXyIl4OUCQLTQUaoUbzxxZK0yLY7cxcxFKvkNhrvx_mv9bFZ4GOl_nFr-rv8EIdTM8A</recordid><startdate>20100105</startdate><enddate>20100105</enddate><creator>Donaldson, S B</creator><creator>Buckley, D L</creator><creator>O'Connor, J P</creator><creator>Davidson, S E</creator><creator>Carrington, B M</creator><creator>Jones, A P</creator><creator>West, C M L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100105</creationdate><title>Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix</title><author>Donaldson, S B ; Buckley, D L ; O'Connor, J P ; Davidson, S E ; Carrington, B M ; Jones, A P ; West, C M L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-e3eb8bf4842ac523eaa8c4164f4568c20e6fcc247d6aa065e3850bd023eaa8ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - blood supply</topic><topic>Adenocarcinoma - radiotherapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Adenosquamous - blood supply</topic><topic>Carcinoma, Adenosquamous - radiotherapy</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Contrast Media</topic><topic>Disease-Free Survival</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follow-Up Studies</topic><topic>Gadolinium DTPA</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Image Processing, Computer-Assisted - statistics & numerical data</topic><topic>Kaplan-Meier Estimate</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm, Residual</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Oncology</topic><topic>Retrospective Studies</topic><topic>Short Communication</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - blood supply</topic><topic>Uterine Cervical Neoplasms - mortality</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donaldson, S B</creatorcontrib><creatorcontrib>Buckley, D L</creatorcontrib><creatorcontrib>O'Connor, J P</creatorcontrib><creatorcontrib>Davidson, S E</creatorcontrib><creatorcontrib>Carrington, B M</creatorcontrib><creatorcontrib>Jones, A P</creatorcontrib><creatorcontrib>West, C M L</creatorcontrib><collection>SpringerOpen</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donaldson, S B</au><au>Buckley, D L</au><au>O'Connor, J P</au><au>Davidson, S E</au><au>Carrington, B M</au><au>Jones, A P</au><au>West, C M L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2010-01-05</date><risdate>2010</risdate><volume>102</volume><issue>1</issue><spage>23</spage><epage>26</epage><pages>23-26</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
There is a need for simple imaging parameters capable of predicting therapeutic outcome.
Methods:
This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (
E
F
) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).
Results:
Tumours with high
E
F
had a significantly poorer probability of DFS than those with low
E
F
(
P
=0.011).
Interpretation:
E
F
is a simple imaging biomarker that should be studied further in a multi-centre setting.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19920831</pmid><doi>10.1038/sj.bjc.6605415</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2010-01, Vol.102 (1), p.23-26 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2813759 |
| source | PubMed Central |
| subjects | Adenocarcinoma - blood supply Adenocarcinoma - radiotherapy Adult Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Adenosquamous - blood supply Carcinoma, Adenosquamous - radiotherapy Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - radiotherapy Contrast Media Disease-Free Survival Drug Resistance Epidemiology Female Female genital diseases Follow-Up Studies Gadolinium DTPA Gynecology. Andrology. Obstetrics Humans Image Processing, Computer-Assisted - methods Image Processing, Computer-Assisted - statistics & numerical data Kaplan-Meier Estimate Magnetic Resonance Imaging - methods Medical sciences Middle Aged Molecular Medicine Neoplasm Metastasis Neoplasm Recurrence, Local - epidemiology Neoplasm, Residual Neovascularization, Pathologic - pathology Oncology Retrospective Studies Short Communication Tumors Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - mortality Uterine Cervical Neoplasms - radiotherapy |
| title | Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix |
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