Transdominant regulation of integrin function: Mechanisms of crosstalk

Transdominant inhibition of integrins or integrin–integrin crosstalk is an important regulator of integrin ligand binding and subsequent signaling events that control a variety of cell functions in many tissues. Here we discuss examples of integrin crosstalk and detail our current understanding of t...

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Bibliographic Details
Published in:Cellular signalling 2010-04, Vol.22 (4), p.578-583
Main Authors: Gonzalez, Annette M., Bhattacharya, Ramona, deHart, Gregory W., Jones, Jonathan C.R.
Format: Article
Language:English
Subjects:
Adaptor proteins
Animals
Cytoskeleton
Cytoskeleton - metabolism
Humans
Integrins - antagonists & inhibitors
Integrins - genetics
Integrins - metabolism
Matrix adhesion
Phosphorylation
Receptors
Signal Transduction
Signaling
Talin - metabolism
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Summary:Transdominant inhibition of integrins or integrin–integrin crosstalk is an important regulator of integrin ligand binding and subsequent signaling events that control a variety of cell functions in many tissues. Here we discuss examples of integrin crosstalk and detail our current understanding of the molecular mechanisms that are involved in this receptor phenomenon. The cytoskeleton associated protein talin is a key regulator of integrin crosstalk. We describe how the interaction of talin and the cytoplasmic tail of β integrin is controlled and how competitive inhibitors of this binding play a role in integrin crosstalk. We conclude with a discussion of how integrin crosstalk impacts the interpretation of integrin inhibitor and knockdown studies in both the laboratory and clinical setting.
ISSN:0898-6568
1873-3913
DOI:10.1016/j.cellsig.2009.10.009