Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy

Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear. Here conditional over-expression of both wild-type and mutant p53 transgenes indicated that, in adult flies, p53 limits life span in females but favors lif...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2009-10, Vol.1 (11), p.903-936
Main Authors: Waskar, Morris, Landis, Gary N, Shen, Jie, Curtis, Christina, Tozer, Kevin, Abdueva, Diana, Skvortsov, Dmitriy, Tavaré, Simon, Tower, John
Format: Article
Language:English
Subjects:
Aging - genetics
Aging - physiology
Animals
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila melanogaster - physiology
Drosophila Proteins - genetics
Drosophila Proteins - physiology
Female
Gene Transfer Techniques
Genotype
Larva - genetics
Larva - growth & development
Larva - physiology
Longevity - genetics
Longevity - physiology
Male
Models, Animal
Models, Biological
Mutation - genetics
Phenotype
Priority Research Paper
Sex Characteristics
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - physiology
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Summary:Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear. Here conditional over-expression of both wild-type and mutant p53 transgenes indicated that, in adult flies, p53 limits life span in females but favors life span in males. In contrast, during larval development, moderate over-expression of p53 produced both male and female adults with increased life span. Mutations of the endogenous p53 gene also had sex-specific effects on life span under control and stress conditions: null mutation of p53 increased life span in females, and had smaller, more variable effects in males. These developmental stage-specific and sex-specific effects of p53 on adult life span are consistent with a sexual antagonistic pleiotropy model.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.100099