Inflammatory processes in Kawasaki disease reach their peak at the sixth day of fever onset: laboratory profiles according to duration of fever

We evaluated the inflammatory indices according to the fever duration in children with Kawasaki disease (KD), and determined duration when the inflammatory processes in KD reach their peak. Children with KD (n=152) were classified into 7 groups according to fever duration: at the third day or earlie...

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Bibliographic Details
Published in:Journal of Korean medical science 2004-08, Vol.19 (4), p.501-504
Main Authors: Lee, Kyung-Yil, Han, Ji-Whan, Hong, Ja-Hyun, Lee, Hyung-Shin, Lee, Joon-Sung, Whang, Kyung-Tai
Format: Article
Language:English
Subjects:
Child, Preschool
Coronary Vessels - pathology
Female
Fever - blood
Humans
Immunoglobulins, Intravenous - therapeutic use
Infant
Inflammation - blood
Inflammation - immunology
Male
Mucocutaneous Lymph Node Syndrome - blood
Mucocutaneous Lymph Node Syndrome - immunology
Mucocutaneous Lymph Node Syndrome - pathology
Mucocutaneous Lymph Node Syndrome - therapy
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Time Factors
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Summary:We evaluated the inflammatory indices according to the fever duration in children with Kawasaki disease (KD), and determined duration when the inflammatory processes in KD reach their peak. Children with KD (n=152) were classified into 7 groups according to fever duration: at the third day or earlier (n=20), fourth (n=33), fifth (n=46), sixth (n=15), seventh (n=15), eighth (n=9), and at the ninth day or later after fever onset (n= 14). The levels of various laboratory indices were determined 3 times: before, 24 hr and 7 days after intravenous immunoglobulin administration (2 g/kg). WBC and neutrophil counts, and C-reactive protein level were the highest at the sixth day. Levels of hemoglobin, albumin, and high density lipoprotein cholestrol were the lowest at the sixth day. Although these indices were not significant statistically between groups, the indices showed either bell-shaped or U-shaped distribution of which peak or trench were at the sixth day. These findiugs showed that the inflammatory processes in KD reach peak on the sixth day of fever onset. This finding is important because a higher single-dose intravenous immunoglobulin treatment before the peak day may help reduce the coronary artery lesions in KD.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2004.19.4.501