Optical Spectroscopy and Imaging for the Noninvasive Evaluation of Engineered Tissues

Optical spectroscopy and imaging approaches offer the potential to noninvasively assess different aspects of the cellular, extracellular matrix, and scaffold components of engineered tissues. In addition, the combination of multiple imaging modalities within a single instrument is highly feasible, a...

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Bibliographic Details
Published in:Tissue engineering. Part B, Reviews Reviews, 2008-12, Vol.14 (4), p.321-340
Main Authors: Georgakoudi, Irene, Rice, William L., Hronik-Tupaj, Marie, Kaplan, David L.
Format: Article
Language:English
Subjects:
Animals
Artificial Organs
Biocompatible Materials
Bioreactors
Cellulose
Diagnostic imaging
Elasticity
Health aspects
Humans
Methods
Microscopy, Confocal
Photons
Scattering, Radiation
Scientific imaging
Spectrum analysis
Spectrum Analysis - methods
Spectrum Analysis, Raman
Technology application
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds
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Summary:Optical spectroscopy and imaging approaches offer the potential to noninvasively assess different aspects of the cellular, extracellular matrix, and scaffold components of engineered tissues. In addition, the combination of multiple imaging modalities within a single instrument is highly feasible, allowing acquisition of complementary information related to the structure, organization, biochemistry, and physiology of the sample. The ability to characterize and monitor the dynamic interactions that take place as engineered tissues develop promises to enhance our understanding of the interdependence of processes that ultimately leads to functional tissue outcomes. It is expected that this information will impact significantly upon our abilities to optimize the design of biomaterial scaffolds, bioreactors, and cell systems. Here, we review the principles and performance characteristics of the main methodologies that have been exploited thus far, and we present examples of corresponding tissue engineering studies.
ISSN:1937-3368
1937-3376
DOI:10.1089/ten.teb.2008.0248