Lysophosphatidic acid (LPA) signaling in vertebrate reproduction

Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA1–5 , and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2010-01, Vol.21 (1), p.17-24
Main Authors: Ye, Xiaoqin, Chun, Jerold
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Breast - metabolism
Cell Communication
Endocrinology & Metabolism
Female
Fundamental and applied biological sciences. Psychology
Genitalia, Female - metabolism
Genitalia, Male - metabolism
Humans
Lysophospholipids - metabolism
Male
Pregnancy
Receptors, Lysophosphatidic Acid - genetics
Receptors, Lysophosphatidic Acid - metabolism
Reproduction
Signal Transduction
Vertebrates: endocrinology
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Summary:Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA1–5 , and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects of vertebrate reproduction. These include ovarian function, spermatogenesis, fertilization, early embryo development, embryo implantation, embryo spacing, decidualization, pregnancy maintenance and parturition. LPA signaling can also have pathological consequences, influencing aspects of endometriosis and ovarian cancer. Here we review recent progress in LPA signaling research relevant to female and male reproduction.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2009.08.003