The Dachshund gene in development and hormone-responsive tumorigenesis

The dachshund ( dac ) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2010-01, Vol.21 (1), p.41-49
Main Authors: Popov, Vladimir M, Wu, Kongming, Zhou, Jie, Powell, Michael J, Mardon, Graeme, Wang, Chenguang, Pestell, Richard G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Differentiation
Drosophila
Drosophila - genetics
Drosophila - growth & development
Drosophila - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Endocrinology & Metabolism
Eye Proteins - genetics
Eye Proteins - metabolism
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Metazoa
Mice
Neoplasm Invasiveness
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Protein Isoforms - genetics
Protein Isoforms - metabolism
Retina - growth & development
Retina - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
Vertebrates: endocrinology
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Summary:The dachshund ( dac ) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2009.08.002