PIP3, PIP2, and Cell Movement—Similar Messages, Different Meanings?

The inositol lipids PI(4,5)P 2 and PI(3,4,5)P 3 are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P 3 seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P 2...

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Bibliographic Details
Published in:Developmental cell 2001-12, Vol.1 (6), p.743-747
Main Authors: Insall, Robert H., Weiner, Orion D.
Format: Article
Language:English
Subjects:
Actins - metabolism
Cell Membrane - metabolism
Cell Movement - physiology
Cytoskeleton - metabolism
Neutrophils - metabolism
Phosphatidylinositol 4,5-Diphosphate - metabolism
Phosphatidylinositols - metabolism
Polymers - chemistry
Proteins - metabolism
Second Messenger Systems - physiology
Signal Transduction - physiology
Wiskott-Aldrich Syndrome Protein
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Summary:The inositol lipids PI(4,5)P 2 and PI(3,4,5)P 3 are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P 3 seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P 2 appears to be present at too high a concentration and homogenous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P 2 acts permissively, restricting new actin polymerization to the region of the plasma membrane.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(01)00086-7