Prdm9 Controls Activation of Mammalian Recombination Hotspots

Mammalian meiotic recombination, which preferentially occurs at specialized sites called hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic variation among offspring. A locus on mouse chromosome 17, which controls activation of recombination at multiple distant hots...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2010-02, Vol.327 (5967), p.835-835
Main Authors: PARVANOV, Emil D, PETKOV, Petko M, PAIGEN, Kenneth
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Animals
Biological and medical sciences
Cell division
Chromosome Mapping
Female
Fundamental and applied biological sciences. Psychology
Gene expression
Genetic recombination
Genic rearrangement. Recombination. Transposable element
Histone-Lysine N-Methyltransferase - chemistry
Histone-Lysine N-Methyltransferase - genetics
Histone-Lysine N-Methyltransferase - metabolism
Humans
Male
Mammals
Meiosis - genetics
Mice
Mice, Inbred C57BL
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Mus musculus
Proteins
Recombination, Genetic
Sequence Analysis, DNA
Testis - metabolism
Zinc Fingers
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Summary:Mammalian meiotic recombination, which preferentially occurs at specialized sites called hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic variation among offspring. A locus on mouse chromosome 17, which controls activation of recombination at multiple distant hotspots, has been mapped within a 181-kilobase interval, three of whose genes can be eliminated as candidates. The remaining gene, Prdm9, codes for a zinc finger containing histone H3K4 trimethylase that is expressed in early meiosis and whose deficiency results in sterility in both sexes. Mus musculus exhibits five alleles of Prdm9; human populations exhibit two predominant alleles and multiple minor alleles. The identification of Prdm9 as a protein regulating mammalian recombination hotspots initiates molecular studies of this important biological control system.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1181495