Inflammation and oncogenesis: a vicious connection

Epidemiological and experimental data suggest a close connection between inflammation and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation impacts most, if not all, stages of tumorigenesis. Molecular and cellular pathways, which connect inflammation and cancer...

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Bibliographic Details
Published in:Current opinion in genetics & development 2010-02, Vol.20 (1), p.65-71
Main Authors: Grivennikov, Sergei I, Karin, Michael
Format: Article
Language:English
Subjects:
Cancer
Colitis - metabolism
Humans
Inflammation - complications
Inflammation Mediators - immunology
Medical Education
Neoplasms - congenital
Neoplasms - immunology
Neoplasms - pathology
NF-kappa B - metabolism
Signal Transduction
STAT3 Transcription Factor - metabolism
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Summary:Epidemiological and experimental data suggest a close connection between inflammation and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation impacts most, if not all, stages of tumorigenesis. Molecular and cellular pathways, which connect inflammation and cancer, have emerged as attractive targets for prevention and therapy. In this review we discuss general mechanisms and concepts of cancer promoting inflammation.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2009.11.004