High-resolution entrainment mapping of gastric pacing: a new analytical tool

Gastric pacing has been investigated as a potential treatment for gastroparesis. New pacing protocols are required to improve symptom and motility outcomes; however, research progress has been constrained by a limited understanding of the effects of electrical stimulation on slow-wave activity. This...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2010-02, Vol.298 (2), p.G314-G321
Main Authors: O'Grady, Gregory, Du, Peng, Lammers, Wim J E P, Egbuji, John U, Mithraratne, Pulasthi, Chen, Jiande D Z, Cheng, Leo K, Windsor, John A, Pullan, Andrew J
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animals
Effects
Electric Stimulation - methods
Electrodes, Implanted
Female
Gastric Emptying - physiology
Gastrointestinal diseases
Gastroparesis - physiopathology
Innovative Methodology
Male
Medical treatment
Microelectrodes
Models, Animal
Porcine Reproductive and Respiratory Syndrome
Stomach - physiology
Studies
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Summary:Gastric pacing has been investigated as a potential treatment for gastroparesis. New pacing protocols are required to improve symptom and motility outcomes; however, research progress has been constrained by a limited understanding of the effects of electrical stimulation on slow-wave activity. This study introduces high-resolution (HR) "entrainment mapping" for the analysis of gastric pacing and presents four demonstrations. Gastric pacing was initiated in a porcine model (typical amplitude 4 mA, pulse width 400 ms, period 17 s). Entrainment mapping was performed using flexible multielectrode arrays (
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00389.2009