Mast cell and T cell communication; amplification and control of adaptive immunity

Abstract Recent advances in understanding the physiological role of mast cells (MCs) point to an important regulatory role for these cells in adaptive immunity. MCs express a diverse array of molecules that can promote their interaction with T cells as well as with other immune cells. New evidence d...

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Bibliographic Details
Published in:Immunology letters 2010-02, Vol.128 (2), p.98-104
Main Authors: Hershko, Alon Y, Rivera, Juan
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Allergy and Immunology
Animals
Cell Communication - immunology
Cell Line
Cells, Cultured
Communication
Humans
Mast cells
Mast Cells - immunology
Mice
Molecular interaction
T cells
T effectors
T-Lymphocytes - immunology
Tregs
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Summary:Abstract Recent advances in understanding the physiological role of mast cells (MCs) point to an important regulatory role for these cells in adaptive immunity. MCs express a diverse array of molecules that can promote their interaction with T cells as well as with other immune cells. New evidence demonstrates that mast cells can directly and indirectly communicate with T cells. They can control both effector and regulatory T cell responses and their activity can in turn be modulated by these interactions. Here we briefly summarize these advances and discuss some of the major challenges in understanding the communication of MCs and T cells.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2009.10.013