Biomimetic Nanowire Coatings for Next Generation Adhesive Drug Delivery Systems

• Published in: Nano letters 2009-02, Vol.9 (2), p.716-720
• Main Authors: Fischer, Kathleen E, Alemán, Benjamin J, Tao, Sarah L, Daniels, R. Hugh, Li, Esther M, Bünger, Mark D, Nagaraj, Ganesh, Singh, Parminder, Zettl, Alex, Desai, Tejal A
• Format: Article
• Language: English
• Subjects: Biomimetic Materials - chemistry; Cell Adhesion; Cell Survival; Condensed matter: structure, mechanical and thermal properties; Cross-disciplinary physics: materials science; rheology; Drug Carriers - chemistry; Drug Delivery Systems - instrumentation; Drug Delivery Systems - trends; Exact sciences and technology; Materials science; Mechanical and acoustical properties of condensed matter; Mechanical properties of nanoscale materials; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanocrystalline materials; Nanoscale materials and structures: fabrication and characterization; Nanowires - chemistry; Nanowires - ultrastructure; Physics; Quantum wires
• ISSN: 1530-6984; 1530-6992
• DOI: 10.1021/nl803219f

Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.1−3 While some chemically modified, microstructured surfaces have been studied in aqueous environments,4,5 adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.