Cortical mapping of naming errors in aphasia

Persons with aphasia vary greatly with regard to clinical profile; yet, they all share one common feature—anomia—an impairment in naming common objects. Previous research has demonstrated that particular naming errors are associated with specific left hemisphere lesions. However, we know very little...

Full description

Saved in:
Bibliographic Details
Published in:Human brain mapping 2009-08, Vol.30 (8), p.2487-2498
Main Authors: Fridriksson, Julius, Baker, Julie M., Moser, Dana
Format: Article
Language:English
Subjects:
Adult
Aged
anomia
Anomia - physiopathology
Aphasia - physiopathology
Biological and medical sciences
Brain - physiopathology
Brain Mapping
Electrocardiography. Vectocardiography
Electrodiagnosis. Electric activity recording
Female
fMRI
Functional Laterality
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Names
Nervous system
neuroimaging
Neuropsychological Tests
paraphasia
Phonetics
Radiodiagnosis. Nmr imagery. Nmr spectrometry
recovery
right hemisphere
Semantics
speech errors
stroke
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Persons with aphasia vary greatly with regard to clinical profile; yet, they all share one common feature—anomia—an impairment in naming common objects. Previous research has demonstrated that particular naming errors are associated with specific left hemisphere lesions. However, we know very little about the cortical activity in the preserved brain areas that is associated with aphasic speech errors. Utilizing functional magnetic resonance imaging (fMRI), we show for the first time that specific speech errors are associated with common cortical activity in different types and severities of aphasia. Specifically, productions of phonemic errors recruited the left posterior perilesional occipital and temporal lobe areas. A similar pattern of activity was associated with semantic errors, albeit in the right hemisphere. This study does not discount variability in cortical activity following left hemisphere stroke; rather, it highlights commonalities in brain modulation in a population of patients with a common diagnosis but vastly different clinical profiles. Hum Brain Mapp 2009. © 2009 Wiley‐Liss, Inc.
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.20683