Effects of anti-hypertensive drugs on esophageal body contraction

AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) press...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2010-02, Vol.16 (8), p.987-991
Main Authors: Yoshida, Koichi, Furuta, Kenji, Adachi, Kyoichi, Ohara, Shunji, Morita, Terumi, Tanimura, Takashi, Nakata, Shuji, Miki, Masaharu, Koshino, Kenji, Kinoshita, Yoshikazu
Format: Article
Language:English
Subjects:
Adult
Antihypertensive Agents - pharmacology
Atenolol - pharmacology
Brief
Calcium Channel Blockers - pharmacology
Esophagus - drug effects
Esophagus - physiology
Gastrointestinal Motility - drug effects
Humans
Losartan - pharmacology
Male
Muscle, Smooth - drug effects
Nifedipine - pharmacology
Peristalsis - drug effects
Sympatholytics - pharmacology
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Summary:AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administ...
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i8.987