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Study of matrix metalloproteinases and their inhibitors in prostate cancer
Background: Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development. Methods: An immunohistochemi...
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| Published in: | British journal of cancer 2010-03, Vol.102 (5), p.922-929 |
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| container_issue | 5 |
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| container_title | British journal of cancer |
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| creator | Escaff, S Fernández, J M González, L O Suárez, A González-Reyes, S González, J M Vizoso, F J |
| description | Background:
Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development.
Methods:
An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed.
Results:
When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (
n
=70; 52.6%). Tumours with high expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence.
Conclusion:
The expression of MMPs and TIMPs seems to have an important role in the molecular biology of prostate carcinomas, and their expression by tumours may be of clinical interest to used as indicators of tumour aggressiveness. |
| doi_str_mv | 10.1038/sj.bjc.6605569 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2833257</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1974723311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-faca7a2ef67b4e39916887ce29a44c40fcf8eb830c9f4b9f53384d80d4efcecc3</originalsourceid><addsrcrecordid>eNp1kc9vFCEUx4nR2LV69aaZmBhPs2WAGeDSxDT-app4UM-EYR5dJjOwAmPsfy-b3W5bk56AfD_vy3vvi9DrBq8bTMVZGtf9aNZdh9u2k0_QqmkpqRtB-FO0whjzGkuCT9CLlMbylFjw5-iE4KbDnJIVuvyRl-GmCraadY7ubzVD1tMUtjFkcF4nSJX2Q5U34GLl_Mb1LoeYyrUqTMo6Q2W0NxBfomdWTwleHc5T9Ovzp58XX-ur71--XXy8qk2LRa6tNpprArbjPQMqZdMJwQ0QqRkzDFtjBfSCYiMt66VtKRVsEHhgYA0YQ0_R-d53u_QzDAZ8jnpS2-hmHW9U0E49VLzbqOvwRxFBKWl5MfhwMIjh9wIpq9klA9OkPYQlKU5pJztGduS7_8gxLNGX6RQhUgomCCvQeg-Zso8UwR5babDahaTSqEpI6hBSKXh7f4AjfptKAd4fAJ2Mnmws-3XpjqMlSdLujM72XCqSv4Z4196jX7_ZV3idlwhHy1v9H0UdtvQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229984824</pqid></control><display><type>article</type><title>Study of matrix metalloproteinases and their inhibitors in prostate cancer</title><source>PubMed Central</source><creator>Escaff, S ; Fernández, J M ; González, L O ; Suárez, A ; González-Reyes, S ; González, J M ; Vizoso, F J</creator><creatorcontrib>Escaff, S ; Fernández, J M ; González, L O ; Suárez, A ; González-Reyes, S ; González, J M ; Vizoso, F J</creatorcontrib><description>Background:
Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development.
Methods:
An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed.
Results:
When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (
n
=70; 52.6%). Tumours with high expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence.
Conclusion:
The expression of MMPs and TIMPs seems to have an important role in the molecular biology of prostate carcinomas, and their expression by tumours may be of clinical interest to used as indicators of tumour aggressiveness.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6605569</identifier><identifier>PMID: 20160732</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/199 ; 692/699/67/589/466 ; 692/700/1750 ; Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Aged ; Angiogenesis ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Drug Resistance ; Epidemiology ; Extracellular matrix ; Follow-Up Studies ; Humans ; Hyperplasia ; Immunoenzyme Techniques ; Male ; Matrix Metalloproteinases - metabolism ; Medical prognosis ; Medical research ; Medical sciences ; Metastasis ; Middle Aged ; Molecular Diagnostics ; Molecular Medicine ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - pathology ; Nephrology. Urinary tract diseases ; Oncology ; Prognosis ; Prostate cancer ; Prostatic Hyperplasia - metabolism ; Prostatic Hyperplasia - pathology ; Prostatic Intraepithelial Neoplasia - metabolism ; Prostatic Intraepithelial Neoplasia - pathology ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Survival Rate ; Tissue Array Analysis ; Tissue Inhibitor of Metalloproteinases - metabolism ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>British journal of cancer, 2010-03, Vol.102 (5), p.922-929</ispartof><rights>The Author(s) 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 2, 2010</rights><rights>Copyright © 2010 Cancer Research UK 2010 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-faca7a2ef67b4e39916887ce29a44c40fcf8eb830c9f4b9f53384d80d4efcecc3</citedby><cites>FETCH-LOGICAL-c508t-faca7a2ef67b4e39916887ce29a44c40fcf8eb830c9f4b9f53384d80d4efcecc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833257/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833257/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23000259$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20160732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Escaff, S</creatorcontrib><creatorcontrib>Fernández, J M</creatorcontrib><creatorcontrib>González, L O</creatorcontrib><creatorcontrib>Suárez, A</creatorcontrib><creatorcontrib>González-Reyes, S</creatorcontrib><creatorcontrib>González, J M</creatorcontrib><creatorcontrib>Vizoso, F J</creatorcontrib><title>Study of matrix metalloproteinases and their inhibitors in prostate cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development.
Methods:
An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed.
Results:
When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (
n
=70; 52.6%). Tumours with high expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence.
Conclusion:
The expression of MMPs and TIMPs seems to have an important role in the molecular biology of prostate carcinomas, and their expression by tumours may be of clinical interest to used as indicators of tumour aggressiveness.</description><subject>631/208/199</subject><subject>692/699/67/589/466</subject><subject>692/700/1750</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Aged</subject><subject>Angiogenesis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Extracellular matrix</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Prostate cancer</subject><subject>Prostatic Hyperplasia - metabolism</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Prostatic Intraepithelial Neoplasia - metabolism</subject><subject>Prostatic Intraepithelial Neoplasia - pathology</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Survival Rate</subject><subject>Tissue Array Analysis</subject><subject>Tissue Inhibitor of Metalloproteinases - metabolism</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kc9vFCEUx4nR2LV69aaZmBhPs2WAGeDSxDT-app4UM-EYR5dJjOwAmPsfy-b3W5bk56AfD_vy3vvi9DrBq8bTMVZGtf9aNZdh9u2k0_QqmkpqRtB-FO0whjzGkuCT9CLlMbylFjw5-iE4KbDnJIVuvyRl-GmCraadY7ubzVD1tMUtjFkcF4nSJX2Q5U34GLl_Mb1LoeYyrUqTMo6Q2W0NxBfomdWTwleHc5T9Ovzp58XX-ur71--XXy8qk2LRa6tNpprArbjPQMqZdMJwQ0QqRkzDFtjBfSCYiMt66VtKRVsEHhgYA0YQ0_R-d53u_QzDAZ8jnpS2-hmHW9U0E49VLzbqOvwRxFBKWl5MfhwMIjh9wIpq9klA9OkPYQlKU5pJztGduS7_8gxLNGX6RQhUgomCCvQeg-Zso8UwR5babDahaTSqEpI6hBSKXh7f4AjfptKAd4fAJ2Mnmws-3XpjqMlSdLujM72XCqSv4Z4196jX7_ZV3idlwhHy1v9H0UdtvQ</recordid><startdate>20100302</startdate><enddate>20100302</enddate><creator>Escaff, S</creator><creator>Fernández, J M</creator><creator>González, L O</creator><creator>Suárez, A</creator><creator>González-Reyes, S</creator><creator>González, J M</creator><creator>Vizoso, F J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100302</creationdate><title>Study of matrix metalloproteinases and their inhibitors in prostate cancer</title><author>Escaff, S ; Fernández, J M ; González, L O ; Suárez, A ; González-Reyes, S ; González, J M ; Vizoso, F J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-faca7a2ef67b4e39916887ce29a44c40fcf8eb830c9f4b9f53384d80d4efcecc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>631/208/199</topic><topic>692/699/67/589/466</topic><topic>692/700/1750</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - secondary</topic><topic>Aged</topic><topic>Angiogenesis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Extracellular matrix</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Molecular Diagnostics</topic><topic>Molecular Medicine</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Prostate cancer</topic><topic>Prostatic Hyperplasia - metabolism</topic><topic>Prostatic Hyperplasia - pathology</topic><topic>Prostatic Intraepithelial Neoplasia - metabolism</topic><topic>Prostatic Intraepithelial Neoplasia - pathology</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Survival Rate</topic><topic>Tissue Array Analysis</topic><topic>Tissue Inhibitor of Metalloproteinases - metabolism</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Escaff, S</creatorcontrib><creatorcontrib>Fernández, J M</creatorcontrib><creatorcontrib>González, L O</creatorcontrib><creatorcontrib>Suárez, A</creatorcontrib><creatorcontrib>González-Reyes, S</creatorcontrib><creatorcontrib>González, J M</creatorcontrib><creatorcontrib>Vizoso, F J</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Escaff, S</au><au>Fernández, J M</au><au>González, L O</au><au>Suárez, A</au><au>González-Reyes, S</au><au>González, J M</au><au>Vizoso, F J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of matrix metalloproteinases and their inhibitors in prostate cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2010-03-02</date><risdate>2010</risdate><volume>102</volume><issue>5</issue><spage>922</spage><epage>929</epage><pages>922-929</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development.
Methods:
An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed.
Results:
When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (
n
=70; 52.6%). Tumours with high expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence.
Conclusion:
The expression of MMPs and TIMPs seems to have an important role in the molecular biology of prostate carcinomas, and their expression by tumours may be of clinical interest to used as indicators of tumour aggressiveness.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20160732</pmid><doi>10.1038/sj.bjc.6605569</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2010-03, Vol.102 (5), p.922-929 |
| issn | 0007-0920 1532-1827 |
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| source | PubMed Central |
| subjects | 631/208/199 692/699/67/589/466 692/700/1750 Adenocarcinoma - metabolism Adenocarcinoma - secondary Aged Angiogenesis Biological and medical sciences Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Extracellular matrix Follow-Up Studies Humans Hyperplasia Immunoenzyme Techniques Male Matrix Metalloproteinases - metabolism Medical prognosis Medical research Medical sciences Metastasis Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Nephrology. Urinary tract diseases Oncology Prognosis Prostate cancer Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Prostatic Intraepithelial Neoplasia - metabolism Prostatic Intraepithelial Neoplasia - pathology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Survival Rate Tissue Array Analysis Tissue Inhibitor of Metalloproteinases - metabolism Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Study of matrix metalloproteinases and their inhibitors in prostate cancer |
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