Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and b...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2008-03, Vol.319 (5871), p.1791-1792
Main Authors: Core, Leighton J, Lis, John T
Format: Article
Language:English
Subjects:
Animals
DNA
Drosophila
Drosophila - genetics
Enzymes
Gene Expression Regulation
Genes
Genetics
Humans
Insects
Mammals
Nucleosomes
Perspectives
Promoter Regions, Genetic
RNA
RNA polymerase
RNA Polymerase II - metabolism
RNA Precursors - metabolism
RNA Processing, Post-Transcriptional
Transcription, Genetic
Transcriptional regulatory elements
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Summary:Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1150843