Body mass index and risk of liver cirrhosis in middle aged UK women: prospective study

Objective To determine the relation between body mass index (BMI) and liver cirrhosis and the contribution that BMI and alcohol consumption make to the incidence of liver cirrhosis in middle aged women in the UK.Design Prospective cohort study (Million Women Study).Setting Women recruited from 1996...

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Bibliographic Details
Published in:BMJ 2010-03, Vol.340 (7747), p.633-633
Main Authors: Liu, Bette, Balkwill, Angela, Reeves, Gillian, Beral, Valerie
Format: Article
Language:English
Subjects:
Adult
Alcohol drinking
Alcohol Drinking - adverse effects
Alcohol related disorders
Alcohol use
Alcohols
Bats
Body Mass Index
Body weight
Cirrhosis
Diabetes
Epidemiologic Methods
Epidemiologic Studies
Exercise
Female
Health Education
Health Promotion
Hospital admissions
Hospitals
Humans
Liver cirrhosis
Liver Cirrhosis - epidemiology
Liver Cirrhosis - etiology
Liver Disease
Liver diseases
Medical research
Middle age
Middle Aged
Middle aged people
Obesity
Obesity - epidemiology
Overweight - epidemiology
Patient admissions
Prospective studies
Smoking
Smoking and Tobacco
Socioeconomic factors
United Kingdom
Women
Womens health
Young Adult
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Summary:Objective To determine the relation between body mass index (BMI) and liver cirrhosis and the contribution that BMI and alcohol consumption make to the incidence of liver cirrhosis in middle aged women in the UK.Design Prospective cohort study (Million Women Study).Setting Women recruited from 1996 to 2001 in NHS breast screening centres and followed by record linkage to routinely collected information on hospital admissions and deaths.Participants 1 230 662 women (mean age 56 years at recruitment) followed for an average of 6.2 years.Main outcome measures Relative risk and absolute risk of first hospital admission with or death from liver cirrhosis adjusted for age, recruitment region, alcohol consumption, smoking, socioeconomic status, and physical activity.Results 1811 women had a first hospital admission with or died from liver cirrhosis during follow-up. Among women with a BMI of 22.5 or above, increasing BMI was associated with an increased incidence of liver cirrhosis: the adjusted relative risk of cirrhosis increased by 28% (relative risk 1.28, 95% confidence interval 1.19 to 1.38; P
ISSN:0959-8138
0959-535X
1468-5833
1756-1833
DOI:10.1136/bmj.c912